# US 10,245,426 B2 · Medical patch > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,245,426 B2 - Document ID: US10245426B2 - Status: Granted - Kind: B2 - Application number: 14/261,534 - Filed: 2014-04-25 - Published: 2015-07-02 - Granted: 2019-04-02 - Earliest claimed: 2013-12-31 - Assignees: Seoul National University RDB foundation; Industry-Academic Cooperation Foundation, Yonsei University - Applicants: Industry-Academic Cooperation Foundation, Yonsei University; Seoul National University R&DB Foundation - Inventors: Hong Koo Baik; Woo Soon Jang; Tae Il Lee; Byung Soo Kim; Suk Ho Bhang; Wan Geun La - Web page: https://patentgrep.com/patent/US10245426B2 ## CPC - A61N 1/0496: {characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives} - A61L 15/26: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)} - A61L 15/42: Use of materials characterised by their function or physical properties (liquid bandages A61L26/00) - A61N 1/0468: {Specially adapted for promoting wound healing} - A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces - A61N 1/3785: {generated by biological activity or substance, e.g. body movement} - B82Y 30/00: Nanotechnology for materials or surface science, e.g. nanocomposites - B82Y 40/00: Manufacture or treatment of nanostructures - H10N 30/30: with mechanical input and electrical output, e.g. functioning as generators or sensors - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES - H10N: ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR ## Abstract A medical patch having an electric potential generating structure which is attachable to a wound to thus regenerate injured skin tissues is provided. The medical patch includes a unit patch having a piezoelectric potential generating structure. The unit patch includes a first layer, a second layer and a piezoelectric nanomaterial disposed between the first and second layers. ## Claims ### Claim 1 A medical patch having an electric potential generating structure which is attachable to a wound to thus regenerate injured skin tissues, the medical patch having a piezoelectric potential generating structure comprising a plurality of unit patches stacked one on another, each of the plurality of unit patches comprising a first layer, a second layer and a plurality of piezoelectric nanorods disposed between the first and second layers, wherein when the medial patch is attached to a skin for use, the piezoelectric potential generating structure converts mechanical energy originating from a movement of muscle into a piezoelectric potential, wherein the plurality of piezoelectric nanorods comprise a plurality of biaxially-grown piezoelectric nanorods, which are aligned horizontally along with in-plane direction of the first layer or the second layer, wherein the plurality of biaxially-grown piezoelectric nanorods have an average length ranging from 2.5 μm to 3 μm and an average diameter ranging from 200 nm to 250 nm, and are symmetrically bent based on middle portion of the nanorods by the muscle movement of the skin to which the patch is attached, wherein when mechanical load is applied to the biaxially-grown piezoelectric nanorods by the muscle movement of the skin, a first half of each of the biaxially-grown piezoelectric nanorods exhibits positively polarized piezoelectric potentials and a second half opposed to the first half of each of the biaxially-grown piezoelectric nanorods exhibits negatively polarized piezoelectric potentials, wherein the first and second layers are flexible such that the medical patch is attachable to the skin for use. ### Claim 2 (depends on 1) The medical patch according to claim 1, wherein the plurality of piezoelectric nanorods is arrayed unidirectionally between the first and second layers. ### Claim 3 (depends on 2) The medical patch according to claim 2, wherein the plurality of piezoelectric nanorods is arrayed unidirectionally to form a single layer between the first and second layers. ### Claim 4 (depends on 3) The medical patch according to claim 3, wherein the first and second layers are made of a material that is able to transfer mechanical energy applied from an outside to the piezoelectric nanorods. ### Claim 5 (depends on 4) The medical patch according to claim 4, wherein the first and second layers are made of a material that is able to transfer piezoelectric potential generated from the plurality of piezoelectric nanorods to a surface thereof. ### Claim 6 (depends on 1) The medical patch according to claim 1, wherein the number of the unit patches which are stacked one on another varies depending on an intended level of potential. ### Claim 7 (depends on 6) The medical patch according to claim 6, wherein the intended level of potential is 1 V or higher. ### Claim 8 (depends on 1) The medical patch according to claim 1, wherein each of the plurality of unit patches shares at least one of the first and second layers with an adjacent unit patch of the plurality of unit patches. ### Claim 9 A method of fabricating a medical patch having an electric potential generating structure which is attachable to a wound to thus regenerate injured skin tissues, the method comprising the following steps of: (a) preparing powders of piezoelectric nanorods; (b) forming a layer of piezoelectric nanorods by dispersing and rubbing the powders of piezoelectric nanorods on a first layer which is coated on a substrate; (c) forming a second layer on the layer of piezoelectric nanorods; and (d) forming a unit patch having a piezoelectric potential generating structure by separating the first layer and the substrate from each other, wherein the piezoelectric nanorods comprise a plurality of biaxially-grown piezoelectric nanorods, which are aligned horizontally along with in-plane direction of the first layer or the second layer, wherein the plurality of biaxially-grown piezoelectric nanorods have an average length ranging from 2.5 μm to 3 μm and an average diameter ranging from 200 nm to 250 nm, wherein when mechanical load is applied to the biaxially-grown piezoelectric nanorods by the muscle movement of the skin, a first half of each of the biaxially-grown piezoelectric nanorods exhibits positively polarized piezoelectric potentials and a second half opposed to the first half of each of the biaxially-grown piezoelectric nanorods exhibits negatively polarized piezoelectric potentials, wherein the first and second layers are flexible such that the medical patch is attachable to the skin for use. ### Claim 10 (depends on 9) The method according to claim 9, wherein the step (b) comprises arraying the plurality of piezoelectric nanorods unidirectionally between the first and second layers. ### Claim 11 (depends on 10) The method according to claim 10, wherein the step (b) comprises arraying the plurality of piezoelectric nanorods unidirectionally to form a single layer between the first and second layers. ### Claim 12 (depends on 11) The method according to claim 11, wherein the first and second layers are made of a material that is able to transfer mechanical energy applied from an outside to the layer of piezoelectric nanorods and that is able to transfer piezoelectric potential generated from the plurality of piezoelectric nanorods to a surface thereof. ### Claim 13 (depends on 12) The method according to claim 12, wherein the first and second layers are flexible such that the patch is attachable to a skin for use. ### Claim 14 (depends on 11) The method according to claim 11, further comprising the step of stacking a plurality of the unit patches one on another. ### Claim 15 (depends on 14) The method according to claim 14, wherein the plurality of biaxially-grown piezoelectric nanorods is fabricated by hydrothermal synthesis. ### Claim 16 A medical patch having an electric potential generating structure which is attachable to a wound to thus regenerate injured skin tissues, the medical patch comprising a unit patch having a piezoelectric potential generating structure, the unit patch comprising a first layer, a second layer and a piezoelectric nanomaterial disposed between the first and second layers, wherein the unit patch generates a piezoelectric potential by a muscle movement of the skin to which the patch is attached, without a separate electric potential generating system, wherein the piezoelectric nanomaterial is a plurality of biaxially-grown piezoelectric nanorods, which are aligned horizontally along with in-plane direction of the first layer or the second layer, wherein the plurality of biaxially-grown piezoelectric nanorods have an average length ranging from 2.5 μm to 3 μm and an average diameter ranging from 200 nm to 250 nm, and are symmetrically bent based on middle portion of the nanorods by the muscle movement of the skin to which the patch is attached, wherein when mechanical load is applied to the biaxially-grown piezoelectric nanorods by the muscle movement of the skin, a first half of each of the biaxially-grown piezoelectric nanorods exhibits positively polarized piezoelectric potentials and a second half opposed to the first half of each of the biaxially-grown piezoelectric nanorods exhibits negatively polarized piezoelectric potentials, wherein the first and second layers are flexible such that the medical patch is attachable to the skin for use. ### Claim 17 (depends on 16) The medical patch according to claim 16, wherein the plurality of piezoelectric nanorods is arrayed unidirectionally between the first and second layers. ### Claim 18 (depends on 17) The medical patch according to claim 17, wherein the plurality of piezoelectric nanorods is arrayed unidirectionally to form a single layer between the first and second layers. ### Claim 19 (depends on 18) The medical patch according to claim 18, wherein the first and second layers are made of a material that is able to transfer mechanical energy applied from an outside to the piezoelectric nanorods. ### Claim 20 (depends on 19) The medical patch according to claim 19, wherein the first and second layers are made of a material that is able to transfer piezoelectric potential generated from the plurality of piezoelectric nanorods to a surface thereof. ### Claim 21 (depends on 18) The medical patch according to claim 18, wherein the medical patch comprises a plurality of the unit patches stacked one on another.