# US 10,245,399 B2 · Automated inspiratory muscle training for patients receiving mechanical ventilation

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- Number: US 10,245,399 B2
- Document ID: US10245399B2
- Status: Granted
- Kind: B2
- Application number: 13/919,310
- Filed: 2013-06-17
- Published: 2013-10-24
- Granted: 2019-04-02
- Earliest claimed: 2008-03-10
- Assignees: University of Florida Research Foundation, Inc.
- Applicants: University of Florida Research Founation, Inc.
- Inventors: Anatole D. Martin; Michael J. Banner; Andrea Gabrielli; Neil Russell Euliano, II
- Web page: https://patentgrep.com/patent/US10245399B2

## CPC

- A61M 16/0057: {Pumps therefor}
- A61B 5/087: Measuring breath flow
- A61B 5/412: {Detecting or monitoring sepsis}
- A61M 16/026: {specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis}
- A61M 16/20: Valves specially adapted to medical respiratory devices
- A61M 16/204: {used for inhalation control}
- A61M 16/205: {used for exhalation control}
- A61M 2016/0027: {pressure meter}
- A61M 2016/0039: {in the inspiratory circuit}
- A61M 2016/0042: {in the expiratory circuit}
- A61M 2205/502: User interfaces, e.g. screens or keyboards
- A61M 2230/40: Respiratory characteristics
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A system and method for automated inspiratory muscle strength exercise includes software for setting a mechanical ventilator for a pressure regulated breath with an initial pressure target that is at the highest pressure setting a patient can tolerate and increasing the pressure target as tolerated.

## Claims

### Claim 1

A system for automated inspiratory muscle strength training of a patient during mechanical ventilation comprising:
a gas delivery device, wherein said gas delivery device comprises an inhalation assembly that provides breathing gas for inspiratory air flow during patient spontaneous inhalation and includes a valve that controls the breathing gas during a pre-determined number of the spontaneous inhalations;
a control module configured to instruct the gas delivery device to control the breathing gas to maintain a pressure adapted to be below a baseline pressure of a mechanical ventilator during the pre-determined number of spontaneous inhalations; and
a sensing assembly, operably connected to the control module, wherein the sensing assembly, through the operable connection to the control module, is configured to monitor the pressure and facilitate control of the gas delivery device to provide breathing gas for inspiratory air flow.

### Claim 2 (depends on 1)

The system of claim 1, wherein the gas delivery device is removably integrated with the mechanical ventilator.

### Claim 3 (depends on 1)

The system of claim 1, wherein the valve is a positive end-expiratory pressure (PEEP) valve that is used in a reverse direction.

### Claim 4 (depends on 1)

The system of claim 1, further comprising a display.

### Claim 5 (depends on 1)

The system of claim 1, further comprising gas delivery settings for the control module to adjust the inspiratory air flow.

### Claim 6 (depends on 1)

The system of claim 1, wherein the gas delivery device delivers the breathing gas at a pressure between 1 cm H2O to 80 cm of H2O below the baseline pressure of the mechanical ventilator.

### Claim 7 (depends on 6)

The system of claim 6, wherein the gas delivery device delivers a breathing gas at a pressure between 1 cm of H2O to 20 cm of H2O below the baseline pressure of the mechanical ventilator.

### Claim 8 (depends on 1)

The system of claim 1, wherein the pressure of the breathing gas controlled by the gas delivery device is determined by a target power of breathing.

### Claim 9 (depends on 8)

The system of claim 8, wherein the target power of breathing is determined by the mechanical ventilator based upon one or more patient-derived parameters.

### Claim 10 (depends on 1)

The system of claim 1, wherein the control module further instructs the gas delivery device to restrict the breathing gas for between twelve to forty spontaneous inhalations over a twenty-four hour period.

### Claim 11 (depends on 1)

The system of claim 1, wherein the inspiratory training pressure comprises 30% to 60% of a maximal inhalation strength.

### Claim 12 (depends on 1)

The system of claim 1, wherein the control module further instructs the gas delivery device to restrict the breathing gas for between two to six sets of six to ten spontaneous inhalations over a twenty-four hour period.

### Claim 13 (depends on 1)

The system of claim 1, wherein the inspiratory training pressure comprises 60% to 80% of a maximal inhalation strength.

### Claim 14 (depends on 1)

The system of claim 1, wherein the control module instructs the gas delivery device to restrict the breathing gas for inspiratory air flow for two to five sets of six to ten spontaneous inhalations in a twenty-four hour period, and wherein the inspiratory air flow is restricted to 70% to 80% of a maximal inhalation strength.