# US 10,245,387 B2 · Medicament delivery device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,245,387 B2 - Document ID: US10245387B2 - Status: Granted - Kind: B2 - Application number: 15/207,871 - Filed: 2016-07-12 - Published: 2018-01-18 - Granted: 2019-04-02 - Earliest claimed: 2016-07-12 - Assignees: Shl Medical AG - Applicants: Carebay Europe Ltd. - Inventors: Slobodan Stefanov; Thad Miley - Web page: https://patentgrep.com/patent/US10245387B2 ## CPC - A61M 5/31595: {Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking} - A61M 5/20: Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 takes precedence) - A61M 5/24: Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic - A61M 5/31513: {Piston constructions to improve sealing or sliding} - A61M 5/31536: {Blocking means to immobilize a selected dose, e.g. to administer equal doses} - A61M 5/31551: {including axial movement of dose setting member} - A61M 5/31585: {the component being manually operated or triggered by an axially moving actuator operated by user, e.g. an axially movable injection button} - A61M 5/31593: {Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir} - A61M 5/31511: {Piston or piston-rod constructions, e.g. connection of piston with piston-rod (A61M5/5066 takes precedence)} - A61M 5/31528: {by means of rotational movements, e.g. screw-thread mechanisms} - A61M 5/31541: {Means preventing setting of a dose beyond the amount remaining in the cartridge} - A61M 2205/581: by audible feedback - A61M 2205/582: by tactile feedback - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A multi-dose medicament delivery device is presented having a housing, a medicament container assembly, a dose drum, a plunger rod, and an activation assembly. The dose drum is supported in the housing via a threaded connection, wherein the dose drum is axially movable with respect to the housing in a backward direction from an initial position to at least one dosing position when rotated in a first direction in order to set a dose to be delivered, and axially movable with respect to the housing in a forward direction from said dosing position to the initial position when rotated in a second, opposite direction in order to deliver the dose set. The plunger rod is operationally associated with the stopper and supported in the housing via a threaded connection, wherein the threaded connection is configured to axially guide the plunger rod toward the device front end when the plunger rod is rotated in the second direction. ## Claims ### Claim 1 A multi-dose medicament delivery device comprising: a device front end; a device back end; a central longitudinal axis; a housing having a housing front end and a housing back end; a medicament container assembly, the medicament container assembly being configured for accommodating a medicament container with a stopper; a dose drum that is supported in the housing via a first threaded connection; wherein the dose drum is axially movable with respect to the housing in a backward direction from an initial position to at least one dosing position when rotated in a first direction in order to set a dose to be delivered; and wherein the dose drum is axially movable with respect to the housing in a forward direction from the dosing position to the initial position when rotated in a second, opposite direction in order to deliver the dose set; a plunger rod that is operationally associated with the stopper and supported in the housing via a second threaded connection, wherein the threaded connection is configured to axially guide the plunger rod toward the device front end when the plunger rod is rotated in the second direction, where the plunger rod has an inner surface with an inwardly radial protruding tooth corresponding to a predetermined dosing position; and an activation assembly comprising: a plunger rod rotator that is coupled to the dose drum and has at least one first deflecting member comprising an outwardly radial protruding tooth; an activator rod that is axially movable with respect to the plunger rod rotator from an uncoupling position to a coupling position, wherein, when the activator rod is in the coupling position and the dose drum is rotated in the second direction from the dosing position the plunger rod does not rotate until the outwardly radial protruding tooth of the at least one first deflecting member engages the inwardly radial protrusion; and at least one second deflecting member that is configured to lock the activator rod with respect to the plunger rod rotator in the coupling position until the dose drum reaches the initial position again. ### Claim 2 (depends on 1) The device according to claim 1, wherein the at least one first deflecting member is deflected away from the central longitudinal axis by axially moving the activator rod towards the device front end. ### Claim 3 (depends on 1) The device according to claim 1, wherein the plunger rod rotator comprises at least two first deflecting members. ### Claim 4 (depends on 1) The device according to claim 1, wherein the plunger rod is provided with at least one first engagement feature along an inner diameter portion thereof; wherein the at least one first deflecting member is provided with at least one second engagement feature; and wherein the at least one first engagement feature is configured to be engaged with the at least one second engagement feature when the plunger rod rotator is operationally coupled with the plunger rod. ### Claim 5 (depends on 1) The device according to claim 1, wherein the activation assembly further comprises a dose activator element, wherein the dose activator element is fixedly connected to the activator rod and to the at least one second deflecting member. ### Claim 6 (depends on 5) The device according to claim 5, wherein the activation assembly further comprises a release spring; wherein the dose activator element is movable against an output axial force of the release spring from a first position to a second position; wherein the dose activator element is movable by the output axial force of the release spring from the second position to the first position; and wherein, when the dose drum is in the dosing position and the dose activator element is moved to the second position, the at least one second deflecting member inhibits the dose activator element from being moved from the second position into the first position by the output axial force of the release spring until the dose drum reaches the initial position again. ### Claim 7 (depends on 1) The device according to claim 1, wherein the activation assembly comprises a locking element and an unlocking element that are both separately positioned with housing such that the activator rod moves relative to both the locking element and the unlocking element when the activator rod moves from the uncoupling position to the coupling position; wherein the at least one second deflecting member is configured to lock the axial position of the activator rod with respect to the plunger rod rotator in the coupling position by mechanically engaging with the locking element; and wherein the unlocking element is configured to disengage the at least one second deflecting member from the locking element. ### Claim 8 (depends on 7) The device according to claim 7, wherein the unlocking element and/or the at least one second deflecting member has a ramped surface, wherein the ramped surface is configured to deflect the at least one second deflecting member towards or away from the central longitudinal axis. ### Claim 9 (depends on 7) The device according to claim 7, wherein the unlocking element is axially movable with respect to the dose drum. ### Claim 10 (depends on 7) The device according to claim 7, wherein the unlocking element is configured to be pressed in the backward direction against the at least one second deflecting member when the dose drum reaches its initial position. ### Claim 11 (depends on 1) The device according to claim 1, wherein the device includes a ratchet mechanism that inhibits rotation of the plunger rod in the first direction. ### Claim 12 (depends on 11) The device according to claim 11, wherein the device comprises a back rotating blocker element and a threaded insert; wherein the back rotating blocker element is connected to the plunger rod in a rotationally fixed manner; and wherein the back rotating blocker element and the threaded insert together form the ratchet mechanism. ### Claim 13 (depends on 1) The device according to claim 1, wherein the activation assembly is operationally associated with the dose drum such that the activation assembly is moved together with the dose drum in the backward direction with respect to the housing when the dose drum is rotated in the first direction. ### Claim 14 (depends on 1) The device according to claim 1, wherein the dose drum is axially movable with respect to the housing in the backward direction to at least two or at least three different predetermined dosing positions, each dosing position corresponding to a predetermined dose to be delivered; wherein the device comprises an indication means for indicating the respective dose. ### Claim 15 (depends on 1) The device according to claim 1, wherein the activation arrangement further comprises a dosing stop element that is operationally associated with the plunger rod via a threaded connection, the dosing stop element being axially movable with respect to the plunger rod and configured to abut the plunger rod and/or an end stop element connected to said plunger rod in a rotationally fixed manner when the plunger rod has been moved axially forward with respect to the medicament container assembly by a predetermined distance. ### Claim 16 (depends on 5) The device according to claim 5, wherein the dose drum, the plunger rod, the plunger rod rotator, the activator rod, and the dose activator element form a sub-assembly that is configured to be pre-assembled before insertion into the housing. ### Claim 17 A multi-dose medicament delivery device comprising: a device front end; a device back end; a central longitudinal axis; a housing having a housing front end and a housing back end; a medicament container assembly, the medicament container assembly being configured for accommodating a medicament container with a stopper; a dose drum that is supported in the housing via a first threaded connection; wherein the dose drum is axially movable with respect to the housing in a backward direction from an initial position to at least one dosing position when rotated in a first direction in order to set a dose to be delivered; and wherein the dose drum is axially movable with respect to the housing in a forward direction from the dosing position to the initial position when rotated in a second, opposite direction in order to deliver the dose set; a plunger rod that is operationally associated with the stopper and supported in the housing via a second threaded connection, wherein the threaded connection is configured to axially guide the plunger rod toward the device front end when the plunger rod is rotated in the second direction; and an activation assembly comprising: a dose activator button; a locking ring; a plunger rod rotator that is coupled to the dose drum and has at least one first deflecting member; an activator rod that is axially movable with respect to the plunger rod rotator from an uncoupling position to a coupling position, wherein, when the activator rod is in the coupling position, the at least one first deflecting member operationally couples the plunger rod rotator with the plunger rod such that the rotation of the dose drum in the second direction from the dosing position to the initial position rotates the plunger rod in said second direction; and where the dose activator button comprising a second deflecting member that engages the locking ring to axially lock the activator rod with respect to the dose drum when the rod rotator is in the coupling position.