# US 10,245,362 B2 · Blood pump for treatment of bradycardia > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,245,362 B2 - Document ID: US10245362B2 - Status: Granted - Kind: B2 - Application number: 15/551,170 - Filed: 2016-02-09 - Published: 2018-01-25 - Granted: 2019-04-02 - Earliest claimed: 2015-02-24 - Assignees: HeartWare, Inc. - Applicants: HeartWare, Inc. - Inventors: Barry M. Yomtov - Web page: https://patentgrep.com/patent/US10245362B2 ## CPC - A61M 60/148: in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices - A61M 60/178: drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices - A61M 60/216: including a rotating member acting on the blood, e.g. impeller - A61M 60/422: the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps - A61M 60/515: Regulation using real-time patient data - A61M 60/569: synchronous with the native heart beat - A61M 60/824: Hydrodynamic or fluid film bearings - A61M 2205/33: Controlling, regulating or measuring - A61M 2205/3303: Using a biosensor - A61M 2205/3334: Measuring or controlling the flow rate - A61M 2205/3365: Rotational speed - A61M 2230/04: Heartbeat characteristics, e.g. ECG, blood pressure modulation - A61N 1/3627: {for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A ventricular assist device incorporating a rotary pump (3) such as a rotary impeller pump implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit (6) supplying power to the pump, one or more sensors (10) for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit (23) connected to the sensors and to the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a normal sinus rhythm mode, with a varying speed synchronized with the cardiac cycle. When a bradycardia arrhythmia is detected, the pump drive circuit may also nm the pump in a sinus bradycardia mode or a heart block mode different from the normal sinus rhythm mode. ## Claims ### Claim 1 A ventricular assist device comprising: a rotary pump configured to be implantable in fluid communication with a ventricle and an artery of a subject to assist blood flow from the ventricle to the artery; a pump drive circuit for applying power to the pump; a pump drive circuit to control the speed of the pump; one or more sensors for sensing one or more electrogram signals in a patient; a signal processing circuit in communication with the sensors and the pump drive circuit, the signal processing circuit being configured to receive the electrogram signals and: determine an impending onset or absence of a bradycardia arrhythmia based on the electrogram signals from the sensors; during the impeding onset of a bradycardia arrhythmia, determine the impending onset of sinus bradycardia or heart block; control power supplied to the pump from the pump drive circuit so as to control the speed of the pump and: operate the pump in a normal sinus rhythm mode in the absence of an arrhythmia; operate the pump in a first modified mode of operation during the impending onset of heart block or sinus bradycardia. ### Claim 2 (depends on 1) The device of claim 1 wherein the pump is a rotary impeller pump. ### Claim 3 (depends on 1) The device of claim 1, wherein the signal processing circuit is configured to adjust the varying speed responsive to a condition of the subject. ### Claim 4 (depends on 3) The device of claim 3, wherein the signal processing circuit adjusts the varying speed in accordance with electrophysiological signals received by the circuit from the sensors. ### Claim 5 (depends on 1) The device of claim 1, wherein the signal processing circuit is configured to control power supplied to the pump so that the varying speed has a substantially fixed phase relationship with the P-wave of the subject's cardiac cycle. ### Claim 6 (depends on 1) The device of claim 1, wherein the signal processing circuit is configured to control power supplied to the pump so that the varying speed has a substantially fixed phase relationship with the R-wave of the subject's cardiac cycle. ### Claim 7 (depends on 1) The device of claim 1, wherein the device further comprises a pacemaker configured to providing a pacing function for conditions of bradycardia. ### Claim 8 (depends on 1) The device of claim 1, wherein the electrophysiological signals include RA, RV and LV waveforms. ### Claim 9 (depends on 8) The device of claim 8, wherein the RA, RV and LV waveforms include at least one bipolar signal. ### Claim 10 (depends on 1) The device of claim 1, wherein the circuit is configured to detect a sinus bradycardia and the first modified mode of operation includes a sinus bradycardia mode different from the normal sinus rhythm mode. ### Claim 11 (depends on 10) The device of claim 10, wherein the sinus bradycardia mode includes a non-pulsatile mode, and wherein the pump runs in a non-pulsatile manner. ### Claim 12 (depends on 10) The device of claim 10, wherein the sinus bradycardia mode includes a sinus bradycardia pulsatile mode different from the normal sinus rhythm mode. ### Claim 13 (depends on 1) The device of claim 1, wherein the circuit is configured to detect a heart block arrhythmia and the second modified mode of operation is a heart block arrhythmia mode different from the normal sinus rhythm mode. ### Claim 14 (depends on 13) The device of claim 13, wherein the heart block arrhythmia mode includes a non-pulsatile mode wherein the pump runs in a non-pulsatile manner. ### Claim 15 (depends on 13) The device of claim 13, wherein the heart block mode includes a pulsatile mode wherein the pump runs in a pulsatile manner unsynchronized with the cardiac cycle of the subject.