# US 10,245,354 B2 · Method for manufacturing hollow needle-shaped body, and hollow needle-shaped body > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,245,354 B2 - Document ID: US10245354B2 - Status: Granted - Kind: B2 - Application number: 15/241,677 - Filed: 2016-08-19 - Published: 2016-12-08 - Granted: 2019-04-02 - Earliest claimed: 2014-02-24 - Assignees: Toppan Printing Co., Ltd. - Applicants: Toppan Printing Co., Ltd. - Inventors: Tomoya Sumida - Web page: https://patentgrep.com/patent/US10245354B2 ## CPC - A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} - A61M 37/0015: {by using microneedles} - B81B 1/008: {Microtips} - B81C 1/00111: {Tips, pillars, i.e. raised structures (microneedles A61M37/0015)} - C08J 7/123: {Treatment by wave energy or particle radiation (C08J7/18 takes precedence)} - A61M 2037/0023: {Drug applicators using microneedles} - A61M 2037/003: {having a lumen} - A61M 2037/0053: {Methods for producing microneedles} - B81B 2201/055: Microneedles - C08J 2367/04: Polyesters derived from hydroxy carboxylic acids, e.g. lactones (C08J2367/06 takes precedence) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - B81B: MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES (piezoelectric, electrostrictive or magnetostrictive elements per se H10N30/00, H10N35/00) - B81C: PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS (making microcapsules or microballoons B01J13/02; processes or apparatus specially adapted for the manufacture or treatment of piezoelectric, electrostrictive or magnetostrictive elements per se H10N30/01) - C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29) ## Abstract A method for manufacturing a hollow needle-shaped body includes producing a needle-shaped body having a substrate and a projection on a first surface of the substrate, and applying a laser beam to a second surface of the substrate opposite to the first surface such that a through hole that penetrates through the substrate and the projection is formed. The substrate and the projection are comprised of crystallized polyglycolic acid. ## Claims ### Claim 1 A hollow needle-shaped body, comprising: a crystallized polyglycolic acid body having a substrate portion and at least one projection portion such that the projection portion is formed on a surface of the substrate portion, wherein the crystallized polyglycolic acid body has a through hole penetrating through the substrate portion and the projection portion and is made of crystallized polyglycolic acid having a degree of crystallization in a range of 40% to 90%. ### Claim 2 (depends on 1) The hollow needle-shaped body of claim 1, wherein a height from the surface of the substrate portion to an apex of the projection portion is in a range of from 0.5 mm to 2.0 mm. ### Claim 3 (depends on 2) The hollow needle-shaped body of claim 2, wherein the crystallized polyglycolic acid body has the through hole penetrating through the substrate portion and the projection portion such that the through hole has a tapered cross section. ### Claim 4 (depends on 2) The hollow needle-shaped body of claim 2, wherein the height divided by a maximum diameter of the projection at a connection of the projection portion and the substrate portion is in a range of from 1.1 to 5. ### Claim 5 (depends on 4) The hollow needle-shaped body of claim 4, wherein the crystallized polyglycolic acid body has the through hole penetrating through the substrate portion and the projection portion such that the through hole has a tapered cross section. ### Claim 6 (depends on 1) The hollow needle-shaped body of claim 1, wherein the crystallized polyglycolic acid body has the through hole penetrating through the substrate portion and the projection portion such that the through hole has a tapered cross section. ### Claim 7 (depends on 1) The hollow needle-shaped body of claim 1, wherein a height from the surface of the substrate portion to an apex of the projection portion is in a range of from 0.7 mm to 1.5 mm. ### Claim 8 (depends on 1) The hollow needle-shaped body of claim 1, wherein the crystallized polyglycolic acid body has the through hole in a plurality. ### Claim 9 (depends on 1) The hollow needle-shaped body of claim 1, wherein the crystallized polyglycolic acid body has the through hole penetrating through the substrate portion and the projection portion such that the through hole penetrates a side surface of the projection portion. ### Claim 10 (depends on 1) The hollow needle-shaped body of claim 1, wherein the crystallized polyglycolic acid body has the through hole penetrating through the substrate portion and the projection portion such that the through hole penetrates an apex of the projection portion. ### Claim 11 A method for manufacturing a hollow needle-shaped body, comprising: producing a crystallized polyglycolic acid body having a substrate portion and a projection portion formed on a first surface of the substrate portion; and applying a laser beam to a second surface of the substrate portion opposite to the first surface such that a through hole that penetrates through the substrate portion and the projection portion is formed, wherein the crystallized polyglycolic acid body is made of crystallized polyglycolic acid having a degree of crystallization in a range of 40% to 90%. ### Claim 12 (depends on 11) The method of claim 11, wherein the laser beam is an excimer laser beam. ### Claim 13 (depends on 12) The method of claim 12, wherein the crystallized polyglycolic acid body is produced such that a height from the first surface to an apex of the projection portion is in a range of from 0.5 mm to 2.0 mm. ### Claim 14 (depends on 13) The method of claim 13, wherein the crystallized polyglycolic acid body is produced such that the height divided by a maximum diameter of the projection portion at a connection of the projection portion and the substrate portion is in a range of from 1.1 to 5. ### Claim 15 (depends on 12) The method of claim 12, wherein the applying of the laser beam comprises applying the laser beam such that the crystallized polyglycolic acid body has the through hole having a tapered cross section. ### Claim 16 (depends on 11) The method of claim 11, wherein the crystallized polyglycolic acid body is produced such that a height from the first surface to an apex of the projection portion is in a range of from 0.5 mm to 2.0 mm. ### Claim 17 (depends on 16) The method of claim 16, wherein the crystallized polyglycolic acid body is produced such that the height divided by a maximum diameter of the projection portion at a connection of the projection portion and the substrate portion is in a range of from 1.1 to 5. ### Claim 18 (depends on 11) The method of claim 11, wherein the applying of the laser beam comprises applying the laser beam such that the crystallized polyglycolic acid body has the through hole having a tapered cross section. ### Claim 19 (depends on 16) The method of claim 16, wherein the applying of the laser beam comprises applying the laser beam such that the crystallized polyglycolic acid body has the through hole having a tapered cross section. ### Claim 20 (depends on 11) The method of claim 11, wherein the the crystallized polyglycolic acid body is produced such that a height from the first surface to an apex of the projection portion is in a range of from 0.7 mm to 1.5 mm.