Compositions and methods for imaging
AssigneeThe Regents of the University of California
InventorsChristopher J. Chang, Alexander R. Lippert
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Abstract
The present disclosure provides compositions for in vivo imaging of hydrogen peroxide; and methods for detecting hydrogen peroxide in vivo. The compositions and methods find use in various diagnostic applications, which are also provided.
Claims20
A method of detecting hydrogen peroxide in a cell, tissue, or organ, or extracellularly in an individual, the method comprising:
- a) administering to the individual a compound of the formula:
- wherein Z is heteroaryl group, wherein the substituted aryl or heteroaryl group comprises one or more R1 substituent groups each independently selected from a halogen, cyano, nitro, trihalomethyl, alkoxy, aryloxy, alkyl, aryl, heterocycle, thiol, thioether, acyl and hydroxyl, wherein the compound includes one or more isotopically labeled atoms capable of being hyperpolarized by dynamic nuclear polarization at one or more positions selected from the keto carbon and any atom of the substituted aryl or heteroaryl group;
- and
- b) detecting a signal produced by the compound upon reaction with hydrogen peroxide, wherein the compound is hyperpolarized and the detecting is by hyperpolarized magnetic resonance imaging.
A method of detecting hydrogen peroxide in a cell, tissue, or organ, or extracellularly in an individual, the method comprising:
- a) administering to the individual a compound of the formula:
- wherein R2 is one or more groups, each R2 independently selected from halogen, cyano, nitro, trihalomethyl, and alkoxy;
- and
- b) detecting a signal produced by the compound upon reaction with hydrogen peroxide, wherein the compound is hyperpolarized and the detecting is by hyperpolarized magnetic resonance imaging.
A method of detecting hydrogen peroxide in a cell, tissue, or organ, or extracellularly in an individual, the method comprising:
- a) administering to the individual a compound of one of the following structures:
- and
- b) detecting a signal produced by the compound upon reaction with hydrogen peroxide, wherein the compound is hyperpolarized and the detecting is by hyperpolarized magnetic resonance imaging.
Dependencies are inferred from the claim text.