# US 10,245,305 B2 · Botulinum toxin therapy for skin disorders

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- Number: US 10,245,305 B2
- Document ID: US10245305B2
- Status: Granted
- Kind: B2
- Application number: 14/689,390
- Filed: 2015-04-17
- Published: 2015-08-06
- Granted: 2019-04-02
- Earliest claimed: 2003-12-09
- Assignees: Allergan, Inc.
- Applicants: Allergan, Inc.
- Inventors: Eric R. First
- Web page: https://patentgrep.com/patent/US10245305B2

## CPC

- A61K 38/4893: {Botulinum neurotoxin (3.4.24.69)}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61P 17/00: Drugs for dermatological disorders
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- C12Y 304/24069: Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61Q 19/00: Preparations for care of the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12Y: ENZYMES
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Methods for treating skin disorders by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a skin disorder.

## Claims

### Claim 1

A method for reducing the occurrence or alleviating a melanin related affliction in a patient in need thereof, the method comprising the step of locally administering a therapeutically effective amount of a botulinum toxin to an area affected by the melanin related affliction, thereby reducing the occurrence or alleviating the melanin related affliction, wherein the melanin related affliction is selected from the group consisting of dermatofibromas, freckles and atypical moles (dysplastic nevi).

### Claim 2 (depends on 1)

The method of claim 1, wherein the botulinum toxin is selected from the group consisting of botulinum toxin types A, B, C, D, E, F and G.

### Claim 3 (depends on 1)

The method of claim 1, wherein the botulinum toxin is a native botulinum toxin.

### Claim 4 (depends on 1)

The method of claim 1, wherein the botulinum toxin is a modified botulinum toxin.

### Claim 5 (depends on 1)

The method of claim 1, wherein the administering is via a transdermal route, subdermal route, intradermal route, or combinations thereof.

### Claim 6 (depends on 1)

The method of claim 1, wherein the therapeutically effective amount is an amount effective to cause a skin pigmentation change.