Compositions and methods for enzymatic treatment of lung disorders
AssigneeLaclede, Inc.
InventorsMichael Pellico, Pamela Bosco
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Abstract
A therapeutic composition for the treatment of lung diseases or disorders and diseases or disorders of the airway passages including pneumonia, acute respiratory failure, and acute respiratory distress syndrome is based on the generation of a biocidal anion by an enzymatic reaction catalyzed by a peroxidase. The peroxide utilized by the peroxidase enzyme can be endogenous or can be generalized by the action of an oxidase enzyme on a suitable substrate.
Claims28
A method of treating a lung disease or condition comprising the step of administering to a patient suffering from the lung disease or condition, a therapeutic composition comprising:
- (a) a peroxidase enzyme being present in a sufficient quantity such that the biocide is produced in a therapeutically effective concentration;
- (b) a salt, wherein the salt is an alkali metal salt of an anion of thiocyanate, iodate and chlorate;
- and
- (c) an aqueous medium in which the peroxidase enzyme and the salt that acts as an oxygen acceptor are stable,
- wherein the therapeutic composition is administered by a route in which the ingredients of the composition reach the lungs and generate the biocide within the lungs to treat the lung disease or condition.
Dependencies are inferred from the claim text.