# US 10,245,284 B2 · Granular composition for oral administration

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,245,284 B2
- Document ID: US10245284B2
- Status: Granted
- Kind: B2
- Application number: 14/829,912
- Filed: 2015-08-19
- Published: 2017-02-23
- Granted: 2019-04-02
- Earliest claimed: 2015-08-19
- Assignees: Alpex Pharma S.A.
- Applicants: Alpex Pharma S.A.
- Inventors: Federico Stroppolo; Gabriele Granata
- Web page: https://patentgrep.com/patent/US10245284B2

## CPC

- A61K 31/785: Polymers containing nitrogen
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K 9/143: {with inorganic compounds}
- A61K 47/02: Inorganic compounds
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention relates to a granular composition for oral suspension characterized by the presence of an insoluble resin and a silica gel.

## Claims

### Claim 1

A granular composition in the form of an oral suspension in water comprising
a non soluble resin selected from the group consisting of Sevelamer carbonate, Sevelamer hydrochloride, and Cholestyramine, and
a highly porous silica gel having a mesoporous structure,
wherein the highly porous silica gel is in the range of 0.1%-5% (w/w).

### Claim 2 (depends on 1)

The granular composition according to claim 1, wherein the highly porous silica gel is in the range of 0.4%-1.0% (w/w).

### Claim 3 (depends on 1)

The granular composition according to claim 1, wherein the non soluble resin is Sevelamer carbonate, and wherein said granular composition further comprises a flavor.

### Claim 4 (depends on 3)

The granular composition according to claim 3, wherein the flavor is selected from the group consisting of: citrus flavor, berry flavor, peach flavor, apricot flavor, mint flavor, anise flavor, grape flavor, cherry flavor and a mixture thereof.

### Claim 5 (depends on 3)

The granular composition according to claim 3, wherein the flavor is citrus flavor, and wherein the granular composition further comprises an artificial sweetener.

### Claim 6 (depends on 5)

The granular composition according to claim 5, wherein the artificial sweetener is aspartame.

### Claim 7 (depends on 5)

The granular composition according to claim 5, wherein the artificial sweetener is sucralose.