# US 10,245,282 B2 · Compositions for sensitive skin

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- Number: US 10,245,282 B2
- Document ID: US10245282B2
- Status: Granted
- Kind: B2
- Application number: 15/796,958
- Filed: 2017-10-30
- Published: 2018-03-29
- Granted: 2019-04-02
- Earliest claimed: 2013-11-22
- Assignees: Mary Kay Inc.
- Applicants: Mary Kay Inc.
- Inventors: David Gan; Tiffany Carle; Michelle Hines; Milagros Sanchez; Patricia Jacoby; Linda Hart
- Web page: https://patentgrep.com/patent/US10245282B2

## CPC

- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 8/63: Steroids; Derivatives thereof
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/73: Polysaccharides
- A61K 8/733: {Alginic acid; Salts thereof}
- A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof
- A61K 8/9711: Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 8/9794: Liliopsida [monocotyledons]
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 9/107: Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)}
- A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)}
- A61K 31/734: Alginic acid
- A61K 36/23: Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 36/33: Cactaceae (Cactus family), e.g. pricklypear or Cereus
- A61K 36/88: Liliopsida (monocotyledons)
- A61K 36/896: Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K 38/011: {from plants}
- A61K 38/16: Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof {(enzyme inhibitors A61K38/005)}
- A61Q 19/005: {Preparations for sensitive skin}
- A61Q 19/08: Anti-ageing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed are compositions and methods for their use that include a combination of hydrolyzed algin, escin, Ruscus aculeatus root extract, ammonium glycyrrhizate, Centella asiatica extract, hydrolyzed yeast protein, and Calendula officinalis flower extract.

## Claims

### Claim 1

A method of treating erythemic skin of a human in need thereof, the method comprising topically applying to the erythemic skin of said human in need thereof a composition comprising a therapeutically effective amount of:
(a) hydrolyzed algin;
(b) escin;
(c) Ruscus aculeatus root extract;
(d) ammonium glycyrrhizate;
(e) Centella asiatica extract;
(f) hydrolyzed yeast protein; and
(g) Calendula officinalis flower extract.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition reduces pro-inflamatory cytokine productin in the skin, and wherein the pro-inflammatory cytokine is TNF-a, IL-6, IL-8, IL-10, IL-12 p40, or GM-CSF.

### Claim 3 (depends on 1)

The method of claim 1, further comprising between 80 to 90% by weight of water.

### Claim 4 (depends on 1)

The method of claim 1, wherein said composition comprises:
(a) 0.005 to 0.05% by weight of hydrolyzed algin;
(b) 0.001 to 0.05% by weight of escin;
(c) 0.001 to 0.01% by weight of Ruscus aculeatus root extract;
(d) 0.001 to 0.01% by weight of ammonium glycyrrhizate;
(e) 0.0005 to 0.005% by weight of Centella asiatica extract;
(f) 0.0003 to 0.003% by weight of hydrolyzed yeast protein; and
(g) 0.0003 to 0.003% by weight of Calendula officinalis flower extract.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition further comprises butylene glycol;
glycerin; propylene glycol; diazolidinyl urea;
PPG-5-ceteth-20; methylparaben; sodium citrate; disodium EDTA; buteth-3; propylparaben; citric acid;
sodium benzotriazolyl butylphenol sulfonate; and panthenol.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition further comprises glycerin; pentylene glycol; glycereth-26; propylene glycol; triethanolamine;
acrylates/C10-30 alkyl acrylate crosspolymer;
diazolidinyl urea;
hydroxy ethylcellulose;
sodium polyacrylate;
methylparaben;
disodium EDTA;
butylene glycol;
phenoxy ethanol;
caprylyl glycol;
propylparaben; and
panthenol.

### Claim 7 (depends on 1)

The method of claim 1, wherein the composition further comprises pentylene glycol; polysilicone-11;
hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;
dimethicone;
squalane;
glyceryl undecylenate; silica;
butylene glycol; triethanolamine; polysorbate 60;
acrylates/C10-30 alkyl acrylate crosspolymer;
hydroxypropyl cyclodextrin; sorbitan isostearate; panthenol; and glycerin.

### Claim 8 (depends on 1)

The method of claim 1, wherein the composition further comprises glycerin; pentylene glycol; glycereth-26; benzyl alcohol; triethanolamine;
acrylates/C10-30 alkyl acrylate crosspolymer;
hydroxy ethylcellulose;
sodium polyacrylate;
di sodium EDTA;
hydroxypropyl cyclodextrin;
butylene glycol;
phenoxy ethanol;
caprylyl glycol; and
panthenol.