# US 10,245,280 B2 · Use of hyaluronic acid for preparing compositions for treating oral cavity aphthas

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- Number: US 10,245,280 B2
- Document ID: US10245280B2
- Status: Granted
- Kind: B2
- Application number: 10/561,670
- Filed: 2004-06-23
- Published: 2006-07-06
- Granted: 2019-04-02
- Earliest claimed: 2003-06-25
- Assignees: Bioplax Limited
- Applicants: Franco Macchi
- Inventors: Franco Macchi
- Web page: https://patentgrep.com/patent/US10245280B2

## CPC

- A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof}
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Use of hyaluronic acid as the sole active ingredient for preparing compositions in particular for topical use for treating oral cavity aphthas.

## Claims

### Claim 1

A method of reducing the number of ulcers in a subject having an episode of Recurrent Oral Aphthous Ulcers (ROAU) said method comprising the steps of:
selecting a subject having an episode of ROAU; and
administering, repeatedly to the selected subject, from the first day to the seventh day of the episode of ROAU, a composition comprising between 0.01 and 1% by weight hyaluronic acid or a salt thereof, said hyaluronic acid or salt thereof being the sole active ingredient and having an average molecular weight of between 800,000 and 4,000,000,
wherein said composition is administered in an amount sufficient to reduce the number of ulcers in the subject by the fifth day of said single episode.

### Claim 2 (depends on 1)

The method as claimed in claim 1, wherein the hyaluronic acid is administered in the form of sodium salt.

### Claim 3 (depends on 2)

The method as claimed in claim 2 wherein said hyaluronic acid sodium salt is topically administered.

### Claim 4 (depends on 3)

The method according to claim 3 wherein said hyaluronic acid is administered in the form of topical compositions containing sodium hyaluronate in concentrations between 0.01 and 1% by weight on the total weight of the compositions.

### Claim 5 (depends on 1)

The method according to claim 1, wherein said average molecular weight of hyaluronic acid is between 1,000,000 and 2,000,000.

### Claim 6 (depends on 1)

The method according to claim 1, wherein said administering reduces the occurrence of new aphthous ulcers.

### Claim 7 (depends on 1)

The method of claim 1, wherein said administering is carried out at least twice daily.