# US 10,245,263 B2 · Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof

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- Number: US 10,245,263 B2
- Document ID: US10245263B2
- Status: Granted
- Kind: B2
- Application number: 15/448,719
- Filed: 2017-03-03
- Published: 2017-06-29
- Granted: 2019-04-02
- Earliest claimed: 2015-12-23
- Assignees: ArQule, Inc.
- Applicants: ArQule, Inc.
- Inventors: Jean-Marc Lapierre; Sudharshan Eathiraj; Nivedita Namdev; Brian Schwartz; Yusuke Ota; Takayuki Momose; Tomoyuki Tsunemi; Hiroaki Inagaki; Kiyoshi Nakayama
- Web page: https://patentgrep.com/patent/US10245263B2

## CPC

- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- C07D 487/04: Ortho-condensed systems
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

## Claims

### Claim 1

A method of treating chronic lymphoid leukemia, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of Formula (I):
or a pharmaceutically acceptable salt, tautomer, prodrug, or solvate thereof.

### Claim 2 (depends on 1)

The method of claim 1, comprising administering to the patient a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

The method of claim 1, comprising administering to the patient a therapeutically effective amount of a compound of Formula (I).

### Claim 4 (depends on 1)

The method of claim 1, wherein the patient is human.