# US 10,245,241 B2 · Nasal irrigation

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- Number: US 10,245,241 B2
- Document ID: US10245241B2
- Status: Granted
- Kind: B2
- Application number: 15/170,706
- Filed: 2016-06-01
- Published: 2017-12-07
- Granted: 2019-04-02
- Earliest claimed: 2016-06-01
- Applicants: Nina S Yoshpe; Ayal Willner; Rafael Akyuz
- Inventors: Nina S Yoshpe; Ayal Willner; Rafael Akyuz
- Web page: https://patentgrep.com/patent/US10245241B2

## CPC

- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 9/0043: {Nose}
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/14: Alkali metal chlorides; Alkaline earth metal chlorides
- A61K 47/02: Inorganic compounds
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A nasal irrigation solution (or composition) for pre- and post-operation sinus surgery and for use as a daily nasal cleanser. The composition, which may be in a powder form, may include lactated ringers with xylitol. This composition may be mixed with sterile water prior to nasal irrigation.

## Claims

### Claim 1

A process for producing and protecting a hygroscopic mixture powder comprising xylitol for use in nasal irrigation, the process comprising:
blending chemical compounds that formulate lactated ringers in a blender to create a uniform mixture, wherein the chemical compounds comprise sodium chloride, sodium lactate powder, potassium chloride, calcium chloride, and xylitol;
grinding the uniform mixture comprising sodium chloride, sodium lactate, powder, potassium chloride, calcium chloride, and xylitol;
blending the grinded uniform mixture comprising sodium chloride, sodium lactate powder, potassium chloride, calcium chloride, and xylitol;
sieving the blended mixture to reduce the blended mixture into the hygroscopic mixture of the lactated ringers with xylitol, for use in nasal irrigation; and
protecting the hygroscopic mixture from moisture and air by inserting the hygroscopic mixture in a sealed package to protect the hygroscopic mixture from moisture and air,
wherein the blending of the chemical compounds comprise 60.50% wt. of sodium chloride, 32.30% wt. of sodium lactate powder, 3.12% wt. of potassium chloride, 2.08% wt. of calcium chloride, and 2.00% wt. of xylitol.

### Claim 2 (depends on 1)

The process of claim 1, wherein the grinding of the uniform mixture comprises grinding the uniform mixture until uniformity between sodium chloride, sodium lactate, powder, potassium chloride, calcium chloride, and xylitol is achieved.

### Claim 3 (depends on 1)

The process of claim 1, wherein the sieving of the blended mixture comprises sieving through a mesh screen to achieve uniformity between sodium chloride, sodium lactate powder, potassium chloride, calcium chloride, and xylitol in the powder form.

### Claim 4

A process for producing and protecting hygroscopic nasal irrigation powder of lactated ringers, comprising:
mixing one or more active ingredients in a blender, wherein the one or more active ingredients comprises lactated ringers or lactated ringers and xylitol;
blending the one or more active ingredients until a uniform mixture is reached;
grinding the uniform mixture of the one or more active ingredients for a predefined period of time to achieve and lower a granular size and to decrease the size of the uniform mixture;
blending the grinded uniform mixture of the one or more active ingredients until a uniformity is achieved between the one or more of the active ingredients;
sieving the blended mixture of the one or more active ingredients to reduce the blended mixture into the hygroscopic nasal irrigation powder; and
protecting the powder form from moisture and air by inserting the hygroscopic nasal irrigation powder in a sealed package that protects the hygroscopic nasal irrigation from moisture and humidity,
wherein the blending of the chemical compounds comprise 60.50% wt. of sodium chloride, 32.30% wt. of sodium lactate powder, 3.12% wt. of potassium chloride, 2.08% wt. of calcium chloride, and 2.00% wt. of xylitol.

### Claim 5 (depends on 4)

The process of claim 4, wherein the grinding of the uniform mixtures depends on the uniformity of the one or more active ingredients.

### Claim 6 (depends on 4)

The process of claim 4, wherein the blending of the chemical compounds comprise 605.00 lbs. of sodium chloride, 323.0 lbs. of sodium lactate powder, 31.20 lbs. of potassium chloride, and 20.80 lbs. of calcium chloride.

### Claim 7 (depends on 1)

The process of claim 1, wherein the blending of the chemical compounds comprise 605.00 lbs. of sodium chloride, 323.0 lbs. of sodium lactate powder, 31.20 lbs. of potassium chloride, and 20.80 lbs. of calcium chloride, and 20.00 lbs. of xylitol.