# US 10,245,238 B2 · Composition for oral intake

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- Number: US 10,245,238 B2
- Document ID: US10245238B2
- Status: Granted
- Kind: B2
- Application number: 15/305,143
- Filed: 2015-05-14
- Published: 2017-08-24
- Granted: 2019-04-02
- Earliest claimed: 2014-05-15
- Assignees: Theravalues Corporation; Hirofumi Takeuchi
- Applicants: Theravalues Corporation; Hirofumi Takeuchi
- Inventors: Hirofumi Takeuchi; Kohei Tahara; Atsushi Imaizumi; Tsukasa Takahashi; Takato Matsui; Hitomi Ozawa
- Web page: https://patentgrep.com/patent/US10245238B2

## CPC

- A61K 31/12: Ketones
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 36/9066: Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/06: Antihyperlipidemics
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 39/06: Free radical scavengers or antioxidants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided is a composition for oral intake, which exhibits improved oral absorbability of curcumin and/or an analog thereof and can be produced conveniently and inexpensively. A complex of curcumin and/or an analog thereof and a water-soluble cellulose derivative is disclosed.

## Claims

### Claim 1

A method for producing a complex of (A) curcumin and/or an analog thereof and (B) a water-soluble cellulose derivative selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, and a mixture thereof, wherein a weight ratio (A/B) is in a range of 0.02 to 10, the method comprising:
dissolving the curcumin and/or the analog thereof and the water-soluble cellulose derivative in a water-organic solvent mixed solvent, to obtain a solution; and
removing water and the organic solvent from the solution.

### Claim 2

A method for producing a complex of (A) curcumin and/or an analog thereof and (B) a water-soluble cellulose derivative selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, and a mixture thereof, wherein a weight ratio (A/B) is in a range of 0.02 to 10, the method comprising:
dissolving the curcumin and/or the analog thereof in an organic solvent, to obtain a first solution;
dissolving the water-soluble cellulose derivative in water, to obtain a second solution;
mixing the first solution with the second solution, to obtain a mixed solution; and
removing water and the organic solvent from the mixed solution.

### Claim 3 (depends on 1, 2)

A complex comprising:
(A) curcumin and/or an analog thereof, and
(B) a water-soluble cellulose derivative selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, and a mixture thereof wherein the complex is prepared by the method of claim 1 or 2, and a weight ratio (A/B) is in a range of 0.02 to 10.

### Claim 4 (depends on 3)

The complex according to claim 3, wherein curcumin and/or the analog thereof comprises curcumin or a turmeric dye.

### Claim 5 (depends on 3)

The complex according to claim 3, wherein the water-soluble cellulose derivative is hydroxypropyl cellulose.

### Claim 6 (depends on 3)

The complex according to claim 3, wherein the complex is obtained by removing a solvent from a water-organic solvent mixed solution comprising curcumin and/or the analog thereof and the water-soluble cellulose derivative.

### Claim 7 (depends on 3)

The complex according to claim 3, wherein curcumin and/or the analog thereof is amorphous.

### Claim 8 (depends on 3)

A composition suitable for oral intake, comprising the complex according to claim 3.

### Claim 9 (depends on 3)

The complex according to claim 3, wherein the complex comprises curcumin.

### Claim 10 (depends on 3)

The complex according to claim 3, wherein the complex comprises the analog of curcumin.

### Claim 11 (depends on 3)

The complex according to claim 3, wherein the water-soluble cellulose derivative is hydroxypropylmethyl cellulose.