# US 10,245,222 B2 · Dentifrice comprising zinc-amino acid complex

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- Number: US 10,245,222 B2
- Document ID: US10245222B2
- Status: Granted
- Kind: B2
- Application number: 15/674,557
- Filed: 2017-08-11
- Published: 2017-11-30
- Granted: 2019-04-02
- Earliest claimed: 2017-08-11
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Long Pan; Shaotang Yuan; Shira Pilch; James Masters; Zhiqiang Liu; Vyoma Patel
- Web page: https://patentgrep.com/patent/US10245222B2

## CPC

- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/042: {Gels}
- A61K 8/20: Halogens; Compounds thereof
- A61K 8/21: Fluorides; Derivatives thereof
- A61K 8/27: Zinc; Compounds thereof
- A61K 8/442: {substituted by amido group(s)}
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/58: Metal complex; Coordination compounds
- A61K 2800/92: Oral administration
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed herein are dentifrices comprising a zinc amino acid halide, which provide a precipitate of zinc oxide upon use with dilution with water and/or saliva. Methods of making and using the dentifrices are also provided.

## Claims

### Claim 1

A dentifrice comprising a zinc-amino acid-halide complex, wherein the amino acid is lysine, and complex is a zinc lysine chloride complex having the chemical structure [Zn(C6H14N2O2)2Cl]+Cl−, either in solution of the cation [Zn(C6H14N2O2)2Cl]+ and the chloride anion, or in solid salt form, optionally in mono- or dihydrate form.

### Claim 2 (depends on 1)

The dentifrice of claim 1, wherein the zinc-amino acid-halide complex is formed from precursors.

### Claim 3 (depends on 2)

The dentifrice of claim 2, wherein the precursors are a zinc ion source, an amino acid source, and a halide source.

### Claim 4 (depends on 3)

The dentifrice of claim 3, wherein the halide source is part of the zinc ion source, the amino acid source, or a halogen acid.

### Claim 5 (depends on 1)

The dentifrice of claim 1, wherein the amount of zinc is 0.05-4% by weight of the composition.

### Claim 6 (depends on 1)

The dentifrice of claim 1, wherein the zinc ion source and amino acid source form the complex, in situ after the composition is applied.

### Claim 7 (depends on 1)

The dentifrice of claim 1, wherein the zinc is solubilized, such that the dentifrice is substantially clear, which provides a zinc precipitate upon use and dilution with saliva and/or rinsing.

### Claim 8 (depends on 1)

The dentifrice of claim 1, further comprising an effective amount of a fluoride ion source.

### Claim 9 (depends on 1)

The dentifrice of claim 1, further comprising an orally acceptable base comprising ingredients selected from one or more of: abrasives, buffering agents, humectants, surfactants, thickeners, gum strips or fragments, breath fresheners, flavoring, fragrance, coloring, antibacterial agents, whitening agents, agents that interfere with or prevent bacterial attachment, calcium sources, phosphate sources, orally acceptable potassium salts, and anionic polymers.

### Claim 10 (depends on 1)

The dentifrice of claim 1, wherein the pH of the dentifrice is from pH 6 to pH 8.

### Claim 11 (depends on 1)

The dentifrice of claim 1, wherein the dentifrice is a substantially clear gel.

### Claim 12 (depends on 1)

A method of manufacturing a dentifrice according to claim 1, comprising the step of adding a zinc ion source together with an amino acid in complex during manufacture.

### Claim 13 (depends on 1)

A method of treating or reducing dental enamel erosion cleaning the teeth, reducing bacterially-generated biofilm and plaque, reducing gingivitis, inhibiting tooth decay and formation of cavities, and/or reducing dentinal hypersensitivity comprising applying a dentifrice according to claim 1 to the teeth, and, optionally, then rinsing with water or aqueous solution sufficient to trigger precipitation of zinc oxide from the gel.