# US 10,245,213 B2 · Device for reconstituting a pharmaceutical composition

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- Number: US 10,245,213 B2
- Document ID: US10245213B2
- Status: Granted
- Kind: B2
- Application number: 15/330,061
- Filed: 2015-01-23
- Published: 2017-05-18
- Granted: 2019-04-02
- Earliest claimed: 2014-01-29
- Assignees: Eveon
- Applicants: Eveon
- Inventors: Arnaud Wattellier; Xavier Payet-Burin
- Web page: https://patentgrep.com/patent/US10245213B2

## CPC

- A61J 1/2093: {Containers having several compartments for products to be mixed}
- A61J 1/1406: {Septums, pierceable membranes}
- A61J 1/20: Arrangements for transferring {or mixing} fluids, e.g. from vial to syringe
- A61J 1/201: {having one piercing end}
- A61J 1/2048: {Connecting means}
- A61J 1/2068: {Venting means}
- A61J 1/2086: {for fluid filtration}
- A61J 1/2096: {Combination of a vial and a syringe for transferring or mixing their contents}
- A61M 5/142: Pressure infusion, e.g. using pumps
- A61M 5/14216: {Reciprocating piston type}
- B65B 31/02: Filling, closing, or filling and closing, containers {or wrappers} in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
- A61J 1/2017: {having three or more piercing ends}
- A61M 2209/045: for filling, e.g. for filling reservoirs
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B65B: MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING (bundling and pressing devices for cigars A24C1/44; devices for tensioning and securing binders adapted to be supported by the article or articles to be bound B25B25/00; applying closure members to bottles, jars or similar containers B67B1/00-B67B6/00; concurrent cleaning, filling and closing of bottles B67C7/00; emptying bottles, jars, cans, casks, barrels or similar containers B67C9/00)

## Abstract

A device for reconstituting a pharmaceutical composition from at least a first component in a first container and a second component in a second container. The device includes a fluidic unit having a first connector coupled to the first container, a second connector coupled to the second container, a pump, and a fluidic circuit connecting the first connector, the second connector and the pump. The first connector includes a crankpin in rotating engagement within a body and including an axial port fluidically couplable to the first container, a radial port fluidically connected to the axial port of the first connector, and at least one channel arranged therein so as to cooperate with the radial ports of the body of the first connector to selectively connect the axial port of the first connector with at least one channel portion of the fluidic circuit depending on the angular position of the crankpin.

## Claims

### Claim 1

A device for reconstituting a pharmaceutical composition from at least a first component contained in a first container and a second component contained in a second container, comprising:
a fluidic unit; and
a power unit releasably coupled to the fluidic unit,
wherein the fluidic unit comprises:
a first connector comprising a body defining an axial chamber and a rotatable crankpin arranged in the axial chamber, the crankpin comprising a mounting interface configured to mechanically couple to the first container, the crankpin further comprising an axial port configured to fluidically couple to the first container when said first container engages the mounting interface, and a radial port fluidically connected to the axial port of the first connector;
a second connector configured to mechanically and fluidically couple to the second container, the second connector comprising an axial port to fluidically couple to the second container when said second container engages the second connector and a radial port in fluidic link with the axial port of the second connector;
a pump; and
a fluidic circuit comprising channel portions connecting the first connector, the second connector and the pump;
wherein the body of the first connector comprises at least three radial ports connected to the fluidic circuit,
wherein the crankpin comprises at least one channel configured to cooperate with the at least three radial ports of the body of the first connector to selectively connect the axial port of the first connector with at least one channel portion of the fluidic circuit depending on the angular position of the crankpin with respect to the body, and
wherein the power unit comprises:
a power mechanism for actuating the pump; and
transmission means adapted to be connected between an actuator and the crankpin for rotating the first container.

### Claim 2 (depends on 1)

The device according to claim 1, comprising a base onto which the power unit is mounted, the base comprising an inclination mechanism for selectively tilting the rotation axis of the first container.

### Claim 3 (depends on 1)

The device according to claim 1, wherein the second connector comprises a filter within the radial or the axial port of said second connector.

### Claim 4 (depends on 1)

The device according to claim 1, wherein the fluidic unit comprises a venting port and the body of the first connector comprises a fourth radial port in fluidic link with said venting port via a channel portion of the fluidic circuit.

### Claim 5 (depends on 4)

The device according to claim 4, wherein the crankpin comprises a channel adapted to connect the venting port to the pump while the pump is connected to the radial port of the crankpin.

### Claim 6 (depends on 1)

The device according to claim 1, wherein the fluidic unit comprises a third connector configured to mechanically and fluidically couple to a third container or an administration means and wherein the body of the first connector comprises a fifth radial port in fluidic link with said crankpin via a channel portion of the fluidic circuit.

### Claim 7 (depends on 6)

The device according to claim 6, further comprising a filter between said fifth radial port and the third connector.

### Claim 8 (depends on 1)

The device according to claim 1, wherein the axial port of the first connector comprises one spike.

### Claim 9 (depends on 1)

The device according to claim 1, wherein the fluidic circuit comprises:
a first channel portion between a first radial port of the body of the first connector and a first port of the pump;
a second channel portion between a second port of the pump and a second radial port of the body of the first connector;
a third channel portion between a third radial port of the body of the first connector and the radial port of the second connector.

### Claim 10 (depends on 1)

The device according to claim 1, wherein the pump is a reversible pump.

### Claim 11 (depends on 1)

The device according to claim 1, wherein the fluidic unit is made of the assembly of two half-shells, wherein the fluidic circuit is distributed between said half-shells.

### Claim 12 (depends on 1)

An assembly for reconstituting a pharmaceutical composition, comprising a reconstitution device according to claim 1, a first container containing a first component coupled to the first connector of said device and a second container containing a second component coupled to the second connector of said device.

### Claim 13 (depends on 12)

The assembly according to claim 12, wherein the first component is a solid form of a pharmaceutical composition and the second component is a solvent.

### Claim 14 (depends on 12)

The assembly according to claim 12, wherein each of the first and second containers is a vial sealed by a septum.

### Claim 15 (depends on 12)

The assembly according to claim 12, wherein the fluidic unit comprises a third connector configured to mechanically and fluidically couple to a third container or an administration means and wherein the body of the first connector comprises a fifth radial port in fluidic link with said crankpin via a channel portion of the fluidic circuit, the assembly further comprising a third container or an administration means coupled to the third connector of said reconstitution device.