# US 10,245,097 B2 · Living tissue bonding system and method for operating living tissue bonding system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,245,097 B2 - Document ID: US10245097B2 - Status: Granted - Kind: B2 - Application number: 15/012,537 - Filed: 2016-02-01 - Published: 2016-05-26 - Granted: 2019-04-02 - Earliest claimed: 2013-08-02 - Assignees: Olympus Corporation - Applicants: Olympus Corporation - Inventors: Yoshitaka Honda; Takashi Irisawa; Kazue Tanaka; Sadayoshi Takami; Toshifumi Katsuragi; Hiroko Sakamoto; Satomi Sakao - Web page: https://patentgrep.com/patent/US10245097B2 ## CPC - A61B 18/085: {Forceps, scissors} - A61B 18/1445: {at the distal end of a shaft, e.g. forceps or scissors at the end of a rigid rod} - A61B 2018/0063: {Sealing} - A61B 2018/00642: {with feedback, i.e. closed loop control} - A61B 2018/00708: {switching the power on or off} - A61B 2018/00791: {Temperature} - A61B 2018/00886: {Duration} - A61B 2018/00994: {combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A living tissue bonding system including: a sandwiching section for sandwiching living tissue; a power source for supplying to the living tissue treatment energy for bonding the living tissue sandwiched by the sandwiching section; a temperature measuring section for measuring a temperature of the living tissue sandwiched by the sandwiching section; a calculation section calculating, from the temperature of the living tissue measured by the temperature measuring section and a time period of applying the treatment energy, a time integral value of the temperature of the living tissue; a comparison section comparing the time integral value of the temperature of the living tissue calculated by the calculation section with a predetermined setting value; and an instruction section giving an instruction based on a result of the comparison by the comparison section. ## Claims ### Claim 1 A living tissue bonding system comprising: a sandwiching section for sandwiching living tissue; a power source for supplying treatment energy to the living tissue for bonding the living tissue sandwiched by the sandwiching section; a temperature measuring section for measuring a temperature of the living tissue sandwiched by the sandwiching section; and a processor and a memory, the processor being programmed to: calculate, from the measured temperature of the living tissue and a time period of applying the treatment energy, a time integral value of the temperature of the living tissue; compare the calculated time integral value of the temperature of the living tissue with a predetermined setting value for obtaining a predetermined joining strength; and give an instruction based on a result of the comparison. ### Claim 2 (depends on 1) The living tissue bonding system according to claim 1, wherein the processor is programmed to control the power source so that application of the treatment energy decreases or ends, based on the instruction. ### Claim 3 (depends on 2) The living tissue bonding system according to claim 2, wherein the sandwiching section applies two or more treatment energies selected a group consisting of heat energy, ultrasound energy, light energy and high frequency power energy to the living tissue; and the processor is programmed to decrease or terminate output of at least one of the treatment energies based on the instruction. ### Claim 4 (depends on 1) The living tissue bonding system according to claim 1, wherein the processor is programmed to make a notification based on the instruction. ### Claim 5 (depends on 4) The living tissue bonding system according to claim 4, wherein the processor is programmed to: calculate a ratio of the predetermined setting value to the time integral value of the temperature of the living tissue; and make a notification of the ratio. ### Claim 6 (depends on 1) The living tissue bonding system according to claim 1, wherein the processor is programmed to set the predetermined setting value, which is to be a target of the time integral value of the temperature of the living tissue. ### Claim 7 (depends on 6) The living tissue bonding system according to claim 6, wherein the memory is configured to store a plurality of different predetermined setting values. ### Claim 8 (depends on 7) The living tissue bonding system according to claim 7, wherein the memory is configured to store treatment conditions corresponding to the plurality of different predetermined setting values; and the processor being programmed to control the power source so that application of the treatment energy decreases or ends based on a selected treatment condition and based on the instruction. ### Claim 9 (depends on 1) The living tissue bonding system according to claim 1, wherein the treatment energy is at least one of heat energy, ultrasound energy, light energy and high frequency power energy. ### Claim 10 (depends on 1) The living tissue bonding system according to claim 1, wherein the sandwiching section comprises a heat generating device for converting the power to heat energy. ### Claim 11 (depends on 10) The living tissue bonding system according to claim 10, wherein the processor is programmed to measure the temperature of the living tissue from an output of the heat generating device. ### Claim 12 (depends on 1) The living tissue bonding system according to claim 1, wherein the processor is programmed to measure the temperature of the living tissue from an output of a temperature sensor. ### Claim 13 (depends on 1) The living tissue bonding system according to claim 1, wherein, when the temperature of the living tissue becomes 50° C. or above, the processor is programmed to start the calculation of the time integral value of the temperature of the living tissue. ### Claim 14 (depends on 1) The living tissue bonding system according to claim 1, wherein the instruction section giving an instruction based on a result of setting an integral of the temperature of the living tissue and a difference between an application start time of the treatment energy and an application end time of the treatment energy as the predetermined setting value and comparing the predetermined setting value with the time integral value. ### Claim 15 A method for operating a living tissue bonding system, the method comprising: supplying, to the living tissue, treatment energy for bonding living tissue sandwiched by a sandwiching section; measuring a temperature of the living tissue sandwiched by the sandwiching section; calculating, from the measured temperature of the living tissue and a time period of applying the treatment energy, a time integral value of the temperature of the living tissue; comparing the calculated time integral value with a predetermined setting value; and giving an instruction based on a result of comparing the calculated time integral value with the predetermined setting value. ### Claim 16 (depends on 15) The method for operating the living tissue bonding system according to claim 15, the method further comprising controlling the power source so that application of the treatment energy decreases or ends, based on the instruction. ### Claim 17 (depends on 16) The method for operating the living tissue bonding system according to claim 16, further comprising: performing treatment by applying two or more treatment energies selected from a group consisting of heat energy, ultrasound energy, light energy and high frequency power energy to the living tissue; and when controlling the power source, decreasing or terminating output of the treatment energies based on the instruction of the instruction section. ### Claim 18 (depends on 15) The method for operating the living tissue bonding system according to claim 15, the method further comprising making a notification based on the instruction. ### Claim 19 (depends on 17) The method for operating the living tissue bonding system according to claim 17, wherein: when comparing the calculated time integral value with the predetermined setting value, calculating a ratio of the predetermined setting value to the calculated time integral value; and making a notification of the calculated ratio. ### Claim 20 (depends on 15) The method for operating the living tissue bonding system according to claim 15, the method further comprising setting a predetermined setting value which is to be a target of the time integral value of the temperature of the living tissue. ### Claim 21 (depends on 20) The method for operating the living tissue bonding system according to claim 20, the method further comprising storing a plurality of different predetermined setting values. ### Claim 22 (depends on 20) The method for operating the living tissue bonding system according to claim 20, the method further comprising: storing treatment conditions corresponding to the plurality of different predetermined setting values; and controlling the power source so that application of the treatment energy decreases or ends based on selected one of the treatment conditions, based on the instruction from the instruction section. ### Claim 23 (depends on 15) The method for operating the living tissue bonding system according to claim 15, further comprising converting power to the treatment energy and treating the living tissue, wherein the power is converted to at least one of heat energy, ultrasound energy, light energy and high frequency power energy and the treatment is performed. ### Claim 24 (depends on 15) The method for operating the living tissue bonding system according to claim 15, further comprising: converting power to the treatment energy and treating the living tissue; and converting the power to heat energy. ### Claim 25 (depends on 22) The method for operating the living tissue bonding system according to claim 22, further comprising measuring the temperature of the living tissue based on an output of a heat generating device that is provided on the sandwiching section. ### Claim 26 (depends on 15) The method for operating the living tissue bonding system according to claim 15, wherein, the temperature of the living tissue is measured from an output of a temperature sensor. ### Claim 27 (depends on 15) The method for operating the living tissue bonding system according to claim 15, wherein, the calculation of the time integral value of the temperature of the living tissue starts when the temperature of the living tissue becomes a predetermined lower limit or above.