# US 10,245,051 B2 · Drug delivery via mechanical vibration balloon > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,245,051 B2 - Document ID: US10245051B2 - Status: Granted - Kind: B2 - Application number: 14/758,557 - Filed: 2013-12-20 - Published: 2015-12-03 - Granted: 2019-04-02 - Earliest claimed: 2012-12-28 - Assignees: Bard Peripheral Vascular, Inc. - Applicants: Bard Peripheral Vascular - Inventors: Richard Samuel Spano - Web page: https://patentgrep.com/patent/US10245051B2 ## CPC - A61B 17/22012: {in direct contact with, or very close to, the obstruction or concrement (for removing obstructions in blood vessels by laser A61B18/245)} - A61M 25/10: Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00}) - A61M 37/0092: {using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis} - A61B 17/320068: {using mechanical vibrations, e.g. ultrasonic (A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745)} - A61B 2017/22014: {the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire} - A61B 2017/22039: {eccentric} - A61B 2017/22061: {for spreading elements apart} - A61B 2017/320088: {with acoustic insulation, e.g. elements for damping vibrations between horn and surrounding sheath} - A61M 2025/105: {having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes} - A61M 2025/1084: {having features for increasing the shape stability, the reproducibility or for limiting expansion, e.g. containments, wrapped around fibres, yarns or strands} - A61M 2025/109: {having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A drug coated inflatable balloon catheter (200) configured to vibrate is disclosed. The vibration can dislodge the drug from the balloon. The vibration can also improve delivery of the drug to deeper layers of a vessel wall. The balloon catheter can include one or more support wires. The support wires can be coupled to an ultrasound transmission member (120). The ultrasound transmission member can transmit ultrasonic vibrations to the support wires and/or the balloon wall. ## Claims ### Claim 1 A drug delivery balloon catheter comprising: an ultrasound transmission member having a proximal end and a distal end; a generator configured to provide longitudinal vibrations to the ultrasound transmission member through the proximal end of the ultrasound transmission member coupled to the generator; a balloon coupled to the distal end of the ultrasound transmission member and being movable between an inflated state and a deflated state; and at least one wire coupled to the ultrasound transmission member and the balloon so as to transmit the longitudinal vibrations parallel to the balloon catheter from the ultrasound transmission member to the balloon such that the balloon is longitudinally vibrated at least when the balloon is in the inflated state. ### Claim 2 (depends on 1) The device of claim 1, further comprising a catheter body having a distal end and at least one lumen extending longitudinally therethrough, the catheter body surrounding at least a portion of the ultrasound transmission member and in fluid connection with the balloon. ### Claim 3 (depends on 1) The device of claim 1, wherein the at least one wire has a proximal end joined to a first location on the ultrasound transmission member and a distal end joined to a second location on the ultrasound transmission member, the second location spaced distally from the first location. ### Claim 4 (depends on 3) The device of claim 3, wherein the first location is proximate a proximal end of the balloon and the second location is proximate a distal end of the device. ### Claim 5 (depends on 3) The device of claim 3, wherein the at least one wire is directly joined to an exterior surface of the ultrasound transmission member at the first location and at the second location. ### Claim 6 (depends on 3) The device of claim 3, wherein the at least one wire is radially distanced from and separated from the ultrasound transmission member between the first location and the second location in the inflated state. ### Claim 7 (depends on 1) The device of claim 1, wherein the device includes four wires coupled to the ultrasound transmission member and contacting a surface of the balloon. ### Claim 8 (depends on 1) The device of claim 1, wherein the device includes twelve wires coupled to the ultrasound transmission member and contacting a surface of the balloon. ### Claim 9 (depends on 1) The device of claim 1, wherein the at least one wire contacts an inner surface of the balloon. ### Claim 10 (depends on 1) The device of claim 1, wherein the at least one wire contacts an outer surface of the balloon. ### Claim 11 (depends on 1) The device of claim 1, wherein the at least one wire is imbedded within the balloon. ### Claim 12 (depends on 1) The device of claim 1, wherein the balloon is coated with at least one therapeutic. ### Claim 13 (depends on 12) The device of claim 12, wherein the at least one therapeutic includes an antistenosis drug. ### Claim 14 A drug-delivery device for vessels comprising: a catheter body having at least one lumen extending longitudinally therethrough; an elongate ultrasound transmission member extending longitudinally through the lumen; and a drug-coated balloon having at least one support wire coupled to the ultrasound transmission member so as to transmit longitudinal vibrations parallel to the catheter body to the drug-coated balloon such that the drug-coated balloon is longitudinally vibrated. ### Claim 15 (depends on 14) The device of claim 14, wherein the ultrasound transmission member extends longitudinally through the drug-coated balloon.