# US 10,244,940 B2 · Optical coherence tomography for measurement on the retina

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- Number: US 10,244,940 B2
- Document ID: US10244940B2
- Status: Granted
- Kind: B2
- Application number: 15/546,365
- Filed: 2016-01-28
- Published: 2018-01-25
- Granted: 2019-04-02
- Earliest claimed: 2015-01-28
- Assignees: Carl Zeiss Meditec AG
- Applicants: Carl Zeiss Meditec AG
- Inventors: Daniel Bublitz; Christoph Nieten
- Web page: https://patentgrep.com/patent/US10244940B2

## CPC

- A61B 3/102: {for optical coherence tomography [OCT]}
- G01B 9/02004: using frequency scans
- G01B 9/02034: {characterised by particularly shaped beams or wavefronts}
- G01B 9/02041: {characterised by particular imaging or detection techniques}
- G01B 9/0205: {of probe head}
- G01B 9/02091: Tomographic interferometers, e.g. based on optical coherence
- G01B 2290/45: Multiple detectors for detecting interferometer signals
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01B: MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS

## Abstract

An optical coherence tomograph that provides wavelength tunable source radiation and an illumination and measurement beam path, a dividing element that divides source radiation into illumination radiation and reference radiation, and collects measurement radiation. The illumination and measurement beam path has scanner. A detection beam path receives measurement radiation and reference radiation and conducts them onto at least one flat panel detector in a superposed manner. A beam splitter separates the measurement radiation from the illumination radiation. The beam splitter conducts the separated measurement radiation to the detection beam path and sets the numerical aperture of the illumination of the illumination field in the eye. An optical element sets the numerical aperture with which the measurement radiation is collected in the eye and a multi-perforated aperture defines the size of an object field and a number of object spots, from which the measurement radiation reaches the flat panel detector.

## Claims

### Claim 1

An optical coherence tomograph for examining a scattering sample to be placed in an object area, the optical coherence tomograph comprising:
an illumination source that emits source radiation of sweepable wavelength;
a dividing element that divides the source radiation into a reference beam path and an illumination beam path for illuminating the object area with illuminating radiation;
optics in the illumination beam path that distribute the illumination radiation into several object spots and that project these object spots to the object area, and a scanner that adjusts the lateral position of the object spots in the object area;
a detection beam path collecting radiation scattered at the object spots as measurement radiation and superimposing this measurement radiation with reference radiation guided through the reference beam path and guiding the superimposed radiations to a spatially resolving detector comprising pixels, wherein the measurement radiation from an individual object spot is guided to a detector spot covering several pixels of the detector with the detector generating signals therefrom; and
a control device processing the signals generated by the detector and generating therefrom an image of a sample provided in the object area.

### Claim 2 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the optics comprise a multi-lens array that distributes the illumination a into the several object spots.

### Claim 3 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the optics comprise a first multi-hole diaphragm that distributes the illumination radiation into the several object spots.

### Claim 4 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the detection beam path comprises a second multi-hole diaphragm defining an object spot field size for the individual objects spots in the object area, from which object spot fields measurement radiation reaches the detector.

### Claim 5 (depends on 4)

The optical coherence tomograph according to claim 4, wherein the second multi-hole diaphragm is located in or close to an intermediate image plane of the collecting of measurement radiation.

### Claim 6 (depends on 1)

The optical coherence tomograph according to claim 1, wherein a multi-lens array is located upstream of the detector, which multi-lens array bundles radiation from each object spot to the assigned detector spot.

### Claim 7 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the detector is located in an image plane of the collecting of the measurement radiation.

### Claim 8 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the detector is located in a far field of the object area.

### Claim 9 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the detection beam path comprises a beam splitter that splits the illumination radiation from the measurement radiation scattered in the object area.

### Claim 10 (depends on 9)

The optical coherence tomograph according to claim 9, wherein the beam splitter comprises a polarizing beam splitter and a lambda/4 plate is located between the object area and the beam splitter, the lambda/4 plate cooperating with the polarizing beam splitter to filter the measurement radiation regarding a polarization state of the measurement radiation.

### Claim 11 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the illumination beam path comprises an optical element which acts on the illumination radiation only and which defines the numerical aperture of illuminating the object area independently from the numerical aperture of collecting the measurement radiation.

### Claim 12 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the reference beam path comprises a multi-lens array which bundles the reference radiation into a multi-spot pattern adapted to the object spots at which the measurement radiation is collected.

### Claim 13 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the scanner shifts the lateral position of the spots during a wavelength sweep of the source radiation and generates a scan signal indicating a deflection status of the scanner, wherein the control device is connected to the scanner and to the radiation source and reads out a wavelength signal indicating an actual wavelength of the source radiation and consequently of the illumination radiation and connected to the detector and reads out measurement signals for each pixel, wherein the control device generates from the wavelength signal and the measurement signals partial images of a sample located in the object area and evaluates the scan signal to combine the partial images into a 3D total image.

### Claim 14 (depends on 1)

The optical coherence tomograph according to claim 1, wherein the sample examined comprises a human eye.

### Claim 15 (depends on 14)

The optical coherence tomograph according to claim 14, wherein the sample examined comprises a retina of the human eye.

### Claim 16 (depends on 14)

The optical coherence tomograph according to claim 14, wherein the illumination radiation is uniformly distributed over a cross section covered in the pupil of the eye, however, allowing for intensity fluctuations of +/−10%.

### Claim 17 (depends on 1)

The optical coherence tomograph according to claim 1, wherein,
the optical coherence tomograph is structured to examine the retina;
the illumination beam path comprises a light-distributing element that distributes the illumination radiation over the spots and that illuminates the retina,
the illumination and measurement beam path comprise a shared front optic and a shared beam splitter that split off the measurement radiation collected at the eye from the illumination radiation guided to the eye, wherein the beam splitter guides the split off measurement radiation to the detection beam path,
the reference beam path provides an optical path length for the reference radiation, which optical path length corresponds to an optical distance from the splitting element to the object spots and back to a point of superposition, and
the detection beam path superimposes the measurement radiation and the reference radiation at the point of superposition and comprises an optical element acting only on the measurement radiation and co-operating with the front optics to define the numerical aperture with which measurement radiation is collected from the eye, wherein further a diaphragm is located upstream of the detector and in or close to an intermediate image plane and defines the size of an object field from which measurement radiation reaches the detector,
wherein the diaphragm upstream of the detector is formed as a first multi-hole diaphragm and a first multi-lens array is located between the first multi-lens diaphragm and the detector, the first multi-lens array bundles radiation emerging from each hole of the first multi-diaphragm onto a dedicated pixel area of the detector which presents a spatial resolution of 4 to 100 pixels in one direction.

### Claim 18 (depends on 17)

The optical coherence tomograph according to claim 17, wherein the dedicated pixel area presents a spatial resolution of 2D pixel area of 5 to 50 pixels or of 5 to 40 pixels per direction.

### Claim 19

A method for optical coherence tomography for examining a sample, including an eye, wherein the method comprises:
providing source radiation, sweeping the wavelength thereof and dividing the source radiation into illumination radiation and reference radiation;
illuminating the sample with the illumination radiation at a multitude of object spots, wherein a scanner is used for shifting the lateral position of the object spots;
guiding the reference radiation through a reference beam path;
collecting illumination radiation backscattered in or at the sample in a form of measurement radiation by imaging the object spots to detector spots;
superimposing the measurement radiation with reference radiation guided through the reference beam path, wherein the detector spots are fed with superimposed radiation; and
the detecting an intensity distribution of the detector spots.

### Claim 20 (depends on 19)

The method according to claim 19, further comprising performing imaging of the detector spots in parallel by filtering the measurement radiation with a multi-hole diaphragm.

### Claim 21 (depends on 19)

The method according to claim 19, further comprising detecting of the intensity distribution by oversampling in which a resolution of the intensity distribution of each detector spot assigned to an object spot is larger than a resolution of illuminating of the sample with the illumination radiation at the multitude of object spots.

### Claim 22 (depends on 21)

The method according to claim 21, further comprising obtaining an image correction from the intensity distribution.

### Claim 23 (depends on 19)

The method according to claim 19, further comprising generating the multitude of object spots by using a multi-lens array.

### Claim 24 (depends on 19)

The method according to claim 19, further comprising generating the multitude of object spots by using a first multi-hole diaphragm.

### Claim 25 (depends on 19)

The method according to claim 19, further comprising imaging the objects spots to the detector spots by using a second multi-lens diaphragm defining a size of object spot fields of the individual detector spots in the sample, and detecting the measurement radiation from the object spot fields.

### Claim 26 (depends on 19)

The method according to claim 19, further comprising locating the second multi-hole diaphragm close or in an intermediate image plane of the imaging.

### Claim 27 (depends on 19)

The method according to claim 19, further comprising providing a multi-lens array upstream of a detector comprising pixels, wherein the multi-lens array bundles each detector spot to several pixels of the detector.

### Claim 28 (depends on 19)

The method according to claim 19, further comprising detecting the intensity distribution of the detector spots in an image plane of the imaging of the object spots.

### Claim 29 (depends on 19)

The method according to claim 19, further comprising detecting the intensity distribution of the detector spots in a far field of the sample.

### Claim 30 (depends on 19)

The method according to claim 19, further comprising separating the illumination radiation from the measurement radiation scattered in the sample by using a beam splitter.

### Claim 31 (depends on 30)

The method according to claim 30, further comprising making or selecting the beam splitter to be a polarizing beam splitter and further comprising locating a lambda/4 plate between the object field and the beam splitter and wherein the lambda/4 plate cooperates with the polarizing beam splitter to filter the measurement radiation regarding a polarization of the measurement radiation.

### Claim 32 (depends on 19)

The method according to claim 19, further comprising independently setting the numerical aperture of the imaging of the object field separate from the numerical aperture of the collecting of the measurement radiation.

### Claim 33 (depends on 19)

The method according to claim 19, further comprising bundling the reference radiation to a multi-spot pattern which is adapted to the object spots at which the measurement radiation is collected.

### Claim 34 (depends on 19)

The method according to claim 19, further comprising shifting the lateral position of the spots during wavelength sweeps of the source radiation and generating partial images of the object based on the wavelength of the source radiation and consequently of the illuminating radiation and based on the detected intensity distribution, and composing the partial images to a 3D total image under consideration of the shift of the lateral position of the spots.

### Claim 35 (depends on 19)

The method according to claim 19, further comprising selecting the sample examined to be a human eye.

### Claim 36 (depends on 35)

The method according to claim 35, further comprising selecting the sample examined to be a retina.

### Claim 37 (depends on 35)

The method according claim 35, further comprising uniformly distributing the illumination radiation over the pupil of the eye within a cross section covered by the illumination radiation, however, allowing for intensity fluctuations of not more than +/−10%.