Analyte sensor and analyte sensing method
AssigneeKYOCERA Corporation
InventorHiroshi Katta
Life of this patent
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Abstract
There are provided an analyte sensor and an analyte sensing method which provide measurements in a wide phase range, a reduction in size, and lowering of current consumption. That is, in an analyte sensor and an analyte sensing method, a detection element (110) which outputs a detection signal in accordance with a change in mass in a detection portion (111) and a reference element (120) which outputs a reference signal in accordance with a change in mass in a reference portion (121) are provided, a phase change value is determined from the detection signal and the reference signal by heterodyne system, and an amount of detection of a target is calculated.
Claims23
An analyte sensor, comprising:
- a detection signal output portion which outputs a detection signal which changes in response to adsorption of a target contained in an analyte or to reaction with the target;
- a reference signal output portion which outputs a reference signal which serves as a reference signal relative to the detection signal;
- a branching section which branches one of the detection signal and the reference signal into a first signal and a second signal, and branches the other signal of the detection signal and the reference signal into a third signal and a fourth signal;
- a computation section which includes a first computation portion which derives a first measurement signal from the first signal and the third signal by heterodyne system, and a second computation portion which derives a second measurement signal from the second signal and the fourth signal by heterodyne system, the second measurement signal being different in phase-difference (excluding phase differences of ±180°) from the first measurement signal;
- a measurement section which
- calculates two first candidate phase change values from the first measurement signal and calculates two second candidate phase change values from the second measurement signal,
- defines a combination of a first phase change value and a second phase change value which are values determined as being closest in phase-difference to each other from among the two first candidate phase change values and the two second candidate phase change values;
- and
- a selection section which selects one of the first phase change value and the second phase change value as a phase change value.
An analyte sensing method, comprising:
- an analyte supply step of feeding an analyte with a target to a detection signal output portion which outputs a detection signal which changes in response to adsorption of the target or to reaction with the target, and a reference signal output portion which outputs a reference signal which serves as a reference signal relative to the detection signal;
- a branching step of branching one of the detection signal and the reference signal into a first signal and a second signal and branching the other of the detection signal and the reference signal into a third signal and a fourth signal;
- a first computation step of deriving a first measurement signal from the first signal and the third signal by heterodyne system;
- a second computation step of deriving a second measurement signal from the second signal and the fourth signal by heterodyne system, the second measurement signal being different in phase-difference (excluding phase differences of ±180°) from the first measurement signal;
- a measurement step of calculating two first candidate phase change values from the first measurement signal, calculating two second candidate phase change values from the second measurement signal, and defining a combination of a first phase change value and a second phase change value which are values determined as being closest in phase-difference to each other from among the two first candidate phase change values and the two second candidate phase change values;
- and
- a selection step of selecting one of the first phase change value and the second phase change value as a phase change value.
Dependencies are inferred from the claim text.