Magnesium sensing membrane for potentiometric ion selective electrode for measuring ionized magnesium and methods of production and use thereof
AssigneeSiemens Healthcare Diagnostics Inc.
InventorsWei Zhang, Kevin Horan
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Abstract
A potentiometric ion selective electrode for detecting ionized magnesium is disclosed that exhibits improved stability upon exposure to surfactant-containing reagents. Kits containing same are also disclosed, along with methods of production and use thereof.
Claims13
A potentiometric ion selective electrode that detects ionized magnesium in a biological sample containing Ca2+ and Mg2+, the potentiometric ion selective electrode comprising:
- an ionophore having a tripodal stereochemical structure, the ionophore being represented by the structure of Formula I or III:
- a lipophilic borate salt, wherein the lipophilic borate salt is present in an amount that provides a mol ratio of lipophilic borate salt to ionophore in a range of from about 75 mol % to about 100 mol %;
- and
- a polymer matrix in which the ionophore and lipophilic borate salt are disposed, wherein the polymer matrix comprises a polymer and a plasticizer;
- wherein the potentiometric ion selective electrode is more selective to Mg2+ than to Ca2+;
- and
- wherein the potentiometric ion selective electrode is substantially stable upon exposure to a reagent comprising a poly(ethylene oxide) surfactant.
A potentiometric ion selective electrode that detects ionized magnesium in a biological sample containing Ca2+ and Mg2+, the potentiometric ion selective electrode comprising:
- an ionophore having a tripodal stereochemical structure, the ionophore being represented by the structure of Formula II:
- a lipophilic borate salt, wherein the lipophilic borate salt is present in an amount that provides a mol ratio of lipophilic borate salt to ionophore in a range of from about 75 mol % to about 100 mol %;
- and
- a polymer matrix in which the ionophore and lipophilic borate salt are disposed, wherein the polymer matrix comprises a polymer and a plasticizer;
- wherein the potentiometric ion selective electrode is more selective to Mg2+ than to Ca2+;
- and
- wherein the potentiometric ion selective electrode is substantially stable upon exposure to a reagent comprising a poly(ethylene oxide) surfactant.
A potentiometric ion selective electrode that detects ionized magnesium in a biological sample containing Ca2+ and Mg2+, the potentiometric ion selective electrode comprising:
- an ionophore having a tripodal stereochemical structure, the ionophore being represented by the structure of Formula I, II, or III:
- a lipophilic borate salt, wherein the lipophilic borate salt is present in an amount that provides a mol ratio of lipophilic borate salt to ionophore in a range of from about 75 mol % to about 85 mol %, and wherein the lipophilic borate salt is selected from the group consisting of potassium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate;
- sodium tetrakis[3,5-bis(trifluoromethyl) phenyl]borate;
- and potassium tetrakis(4-chlorophenyl)borate;
- and
- a polymer matrix in which the ionophore and lipophilic borate salt are disposed, wherein the polymer matrix comprises a polymer and a plasticizer;
- wherein the potentiometric ion selective electrode is more selective to Mg2+ than to Ca2+;
- and
- wherein the potentiometric ion selective electrode is substantially stable upon exposure to a reagent comprising a poly(ethylene oxide) surfactant.
Dependencies are inferred from the claim text.