Biological tissue analysis by inverse spectroscopic optical coherence tomography
AssigneeNorthwestern University
InventorsVadim Backman, Ji Yi
Life of this patent
Estimating the term…
Abstract
A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio or scattering coefficient μs, and the back-scattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.
Claims20
A method comprising:
- generating, using an inverse spectroscopic optical coherence tomography (ISOCT) apparatus, three-dimensional (3D) data using an inverse Fourier transform of interferometric data related to a tissue sample;
- generating, using the ISOCT apparatus, four-dimensional (4D) data using a short frequency Fourier transform of the interferometric data;
- calculating, using an ISOCT apparatus, a mass fractal dimension value of the tissue sample based on the 4D data;
- calculating, using an ISOCT apparatus, a backscattering coefficient of the tissue sample based on the 3D data;
- calculating, using an ISOCT apparatus, a scattering coefficient of the tissue sample based on the 3D data and 4D data;
- and
- determining, using an ISOCT apparatus, a type of tissue based on at least one of the mass fractal dimension value, the backscattering coefficient, and the scattering coefficient of the tissue sample.
An apparatus comprising:
- a computer connected to a laser source, an interferometer, and a charge coupled device camera, the computer to control the interferometer and the camera to form an inverse spectroscopic optical coherence tomography (ISOCT) system, the computer having a processor to:
- generate three-dimensional (3D) data using an inverse Fourier transform of interferometric data created by the interferometer and collected by the charge coupled device camera related to a tissue sample;
- generate four-dimensional (4D) data using a short frequency Fourier transform of the interferometric created by the interferometer and collected by the charge coupled device camera data;
- calculate a mass fractal dimension value of the tissue sample based on the 4D data;
- calculate a backscattering coefficient of the tissue sample based on the 3D data;
- calculate a scattering coefficient of the tissue sample based on the 3D data and 4D data;
- and
- determine a type of tissue based on at least one of the mass fractal dimension value, the backscattering coefficient, and the scattering coefficient of the tissue sample.
A non-transitory computer readable storage medium including instructions that, when executed, causes a processor configured as part of an inverse spectroscopic optical coherence tomography (ISOCT) system to at least:
- generate three-dimensional (3D) data using an inverse Fourier transform of interferometric data related to a tissue sample;
- generate four-dimensional (4D) data using a short frequency Fourier transform of the interferometric data;
- calculate a mass fractal dimension value of the tissue sample based on the 4D data;
- calculate a backscattering coefficient of the tissue sample based on the 3D data;
- calculate a scattering coefficient of the tissue sample based on the 3D data and the 4D data;
- and
- determine a type of tissue based on at least one of the mass fractal dimension value, the backscattering coefficient, and the scattering coefficient of the tissue sample.
Dependencies are inferred from the claim text.