Method for in vitro diagnosis or prognosis of testicular cancer
AssigneeBiomerieux
InventorsMaud Arsac, Bertrand Bonnaud, Francois Mallet, Jean-Philippe Pichon
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Abstract
The invention relates to a method for in vitro diagnosis or prognosis of testicular cancer which comprises a step of detecting the presence or absence of at least one expression product from at least one nucleic acid sequence selected from the sequences identified in SEQ ID NOS: 1 to 6 or from the sequences which exhibit at least 99% identity with one of the sequences identified in SEQ ID NOS: 1 to 6, to isolated nucleic acid sequences and to the use thereof as a testicular cancer marker.
Claims24
A method of detecting at least one HERV-W mRNA transcript, comprising:
- obtaining a biological sample that is collected from a person suspected of suffering from testicular cancer;
- and
- detecting whether one or more HERV-W mRNA transcripts are expressed by assaying the biological sample,
- wherein the one or more HERV-W mRNA transcripts include an HERV-W mRNA transcript expressed from a genomic sequence having at least 99% sequence identity with SEQ ID NO:
- 4.
A method of detecting at least one HERV-W mRNA transcript, comprising:
- obtaining a biological sample that is collected from a person suspected of suffering from testicular cancer;
- and
- detecting whether one or more HERV-W mRNA transcripts are expressed by assaying the biological sample,
- wherein the one or more HERV-W mRNA transcripts include an HERV-W mRNA transcript having at least 99% sequence identity with SEQ ID NO:
- 10.
A method of detecting HERV-W mRNA transcripts, comprising:
- obtaining a biological sample that is collected from a person suspected of suffering from testicular cancer;
- and
- assaying the biological sample to detect whether an HERV-W mRNA transcript is expressed from each of:
- (i) a first genomic sequence having at least 99% sequence identity with SEQ ID NO:
- 1;
- (ii) a second genomic sequence having at least 99% sequence identity with SEQ ID NO:
- 2;
- (iii) a third genomic sequence having at least 99% sequence identity with SEQ ID NO:
- 3;
- (iv) a fourth genomic sequence having at least 99% sequence identity with SEQ ID NO:
- 4;
- (v) a fifth genomic sequence having at least 99% sequence identity with SEQ ID NO:
- 5;
- and
- (vi) a sixth genomic sequence having at least 99% sequence identity with SEQ ID NO:
- 6.
A method of detecting HERV-W mRNA transcripts, comprising:
- obtaining a biological sample that is collected from a person suspected of suffering from testicular cancer;
- and
- assaying the biological sample to detect whether each of the following is expressed:
- (i) a first HERV-W mRNA transcript having at least 99% sequence identity with SEQ ID NO:
- 7;
- (ii) a second HERV-W mRNA transcript having at least 99% sequence identity with SEQ ID NO:
- 8;
- (iii) a third HERV-W mRNA transcript having at least 99% sequence identity with SEQ ID NO:
- 9;
- (iv) a fourth HERV-W mRNA transcript having at least 99% sequence identity with SEQ ID NO:
- 10;
- (v) a fifth HERV-W mRNA transcript having at least 99% sequence identity with SEQ ID NO:
- 11;
- and
- (vi) a sixth HERV-W mRNA transcript having at least 99% sequence identity with SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.