Eye disease treatment agent, screening method therefor, and method for predicting rejection response associated with retinal pigment epithelial cell transplant

A method of producing an allogeneic retinal pigment epithelial (RPE) cell as an active ingredient of a therapeutic agent for a patient with an ophthalmic disease, comprising:

• (i) a step of examining genotypes of alleles of an HLA-A gene locus, an HLA-B gene locus, and an HLA-DR gene locus of patient-derived T cells;
• (ii) a step of producing the RPE by obtaining RPE directly from an eye, by isolating RPE from an eye and growing it in a culture medium, by differentiating a stem cell into the RPE, or by differentiating a progenitor cell into the RPE,
• wherein the produced RPE is allogeneic, has an allele matching the allele at each gene locus examined in step (i), and does not have the same HLA haplotype as the patient-derived T cells.