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US 10,240,186 B2Granted
Devices, systems, and methods for magnetic separation
AssigneeFluxion Biosciences Inc.
InventorsCristian Ionescu-Zanetti, Joshua Tanner Nevill, Michael Schwartz, Carolyn G. Conant, Roger Rudoff
Life of this patent
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Abstract
Methods, microfluidic devices, and instruments for magnetic separation of particles from a fluid are described. Examples include microfluidic devices having a removable portion. Examples include microfluidic devices having one or more regions of reduced fluid velocity. Examples further including instruments having pneumatic interfaces. Examples further includes instruments having controllable magnets, imaging components, or combinations thereof.
Claims24
A method comprising:
- providing a fluid containing a plurality of particles having magnetic labels in a microfluidic device, wherein the microfluidic device includes:
- a first substrate at least partially defining a fluidic feature having an opening;
- a second substrate reversibly forming a portion of the fluidic feature by covering the opening;
- separating the plurality of particles having magnetic labels from the fluid during flow of the fluid in the microfluidic device at least in part by generating a magnetic field across the microfluidic device such that the plurality of particles having magnetic labels are transferred to the second substrate;
- and
- removing the second substrate including the plurality of particles having magnetic labels from the opening.
3 more elements
Dependencies are inferred from the claim text.