Modulation of synaptic maintenance
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsBen A. Barres, Alexander H. Stephan, Beth A. Stevens
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Abstract
C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including treating and preventing neurodegenerative diseases such as Alzheimer's disease.
Claims21
A method of treating a patient suffering from cognitive decline, the method comprising administering to the patient an antibody that binds to C1q, C1s, or C1r.
A method of inhibiting synapse loss in a patient suffering from cognitive decline, the method comprising administering to the patient an antibody that binds to C1q, C1s, or C1r.
Dependencies are inferred from the claim text.