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US 10,240,151 B2Granted
Compounds and methods for enhanced cellular uptake
AssigneeRegulus Therapeutics Inc.
InventorBalkrishen Bhat
Life of this patent
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Abstract
Described herein are conjugated modified oligonucleotides that are complementary to a target RNA. The conjugate facilitates cellular uptake of the modified oligonucleotide, resulting improved potency.
Claims21
A compound comprising the structure:
- wherein each N of Nm is, independently, a modified or unmodified nucleoside and m is 1, 2, or 3;
- at least one of X1 and X2 is a phosphodiester linkage;
- MO is a modified oligonucleotide;
- wherein when m is greater than 1, each modified or unmodified nucleoside of Nm is connected to adjacent modified or unmodified nucleosides of Nm by a phosphodiester internucleoside linkage or a phosphorothioate internucleoside linkage;
- and wherein the modified oligonucleotide consists of 8 to 25 linked nucleosides.
2 more elements
Dependencies are inferred from the claim text.