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AssigneeTechnion Research & Development Foundation Limited
InventorsRoee Amit, Alexey Tomsov, Orna Atar, Liron Abrahami, Yael Annis, Roni Cohen, Alexandra Ereskovsky, Noa Katz, Lior Levy, Maayan Lufton, Tal Ofek, Sagi Sheinkman, Nitzan Shmuel, Inbal Vaknin, Ruth Veksler, Adi Yannai
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Chimeric polypeptides comprising a dihydrotestosterone (DHT) reductase moiety, such as 3 alpha-hydroxysteroid dehydrogenase (3α-HSD), fused to a signal peptide moiety, polynucleotides encoding same, and compositions comprising at least one microorganism cell capable of secreting the chimeric polypeptide, are provided. Further provided are methods and kits for treating, preventing or ameliorating androgen-dependent disorders, including but not limited to androgenic alopecia.
A polynucleotide molecule encoding a chimeric polypeptide comprising a first moiety and a second moiety, said first moiety is a dihydrotestosterone (DHT) reductase and said second moiety is a bacterial signal peptide comprising the amino acid sequence selected from the group consisting of SEQ ID NOs:
A kit for treating an androgen-dependent disorder, the kit comprising a first composition comprising a first microorganism cell, said first microorganism cell comprises a first polynucleotide sequence encoding a chimeric polypeptide comprising a first moiety and a second moiety, said first moiety is a dihydrotestosterone (DHT) reductase and said second moiety is a bacterial signal peptide comprising the amino acid sequence selected from the group consisting of SEQ ID NOs:
Dependencies are inferred from the claim text.