Method for preparing nanolipids with encapsulated alcohol
AssigneeNuVessl, Inc.
InventorMichael W. Fountain
Life of this patent
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Abstract
A method for preparing ethanol-containing nanolipid particles, which can be used in food products, frozen desserts, or beverages. The method comprises nanolipidic vehicles in which ethanol-containing substances are encapsulated, said ethanol-containing nanolipidic vehicles can be combined with food products, desserts or beverage ingredients including those that are subsequently frozen. The food product, dessert or beverage can remain in a frozen state during consumption by an individual. A composition comprising ethanol-containing nanolipid particles, which can be used in food products, frozen desserts, or beverages.
Claims20
A method for making ethanol-loaded nanolipid particle (NLP) carriers comprising the steps of:
- a) providing a monophasic optically clear precursor stock having phospholipids solubilized in ethanol and water;
- b) diluting said precursor stock with an ethanol solvent to produce a solvent-diluted precursor stock having substantially unloaded nanolipid particles (NLPs), wherein said diluting of said precursor stock with said ethanol solvent is at a ratio ranging from about 1 part precursor stock to about 20 parts ethanol solvent to a ratio ranging from about 1 part precursor stock to about 0.3 parts ethanol solvent;
- c) mixing an ethanol-containing substance suitable for human consumption with an aqueous solvent to produce an aqueous-ethanol monophase;
- and
- d) combining said solvent-diluted precursor stock produced in step (b) with said aqueous-ethanol monophase produced in step (c), wherein the ethanol-containing substance from said aqueous-ethanol monophase in step (c) becomes loaded as a passenger within the nanolipid particles (NLPs) in step (b) forming ethanol-loaded nanolipid particle (NLP) carriers, said ethanol-loaded nanolipid particle (NLP) carriers are sized from 20 nm-300 nm.
A method for making ethanol-loaded nanolipid particle (NLP) carriers comprising the steps of:
- a) providing a monophasic optically clear precursor stock having phospholipids selected from phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidylinositol (PI), or mixtures thereof, solubilized in ethanol and water;
- b) diluting said precursor stock with an ethanol solvent to produce a solvent-diluted precursor stock having substantially unloaded nanolipid particles (NLPs), wherein said diluting of said precursor stock with said ethanol solvent is at a ratio ranging from about 1 part precursor stock to about 20 parts ethanol solvent to a ratio ranging from about 1 part precursor stock to about 0.3 parts ethanol solvent;
- c) mixing an ethanol-containing substance suitable for human consumption with an aqueous solvent to produce an aqueous-ethanol monophase;
- said aqueous-ethanol monophase comprising from 12.5% ethanol in water (volume/volume) to 50% ethanol in water (volume/volume);
- and
- d) combining said solvent-diluted precursor stock produced in step (b) with said aqueous-ethanol monophase produced in step (c), wherein the ethanol-containing substance from said aqueous-ethanol monophase in step (c) becomes loaded as a passenger within the nanolipid particles (NLPs) in step (b) forming ethanol-loaded nanolipid particle (NLP) carriers.
A method for making ethanol-loaded nanolipid particle (NLP) carriers comprising the steps of:
- a) providing a monophasic optically clear precursor stock having phospholipids selected from phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidylinositol (PI), or mixtures thereof, solubilized in ethanol and water;
- b) diluting said precursor stock with an ethanol solvent to produce a solvent-diluted precursor stock having substantially unloaded nanolipid particles (NLPs), wherein said diluting of said precursor stock with said ethanol solvent is at a ratio ranging from about 1 part precursor stock to about 20 parts ethanol solvent to a ratio ranging from about 1 part precursor stock to about 0.3 parts ethanol solvent;
- c) mixing an ethanol-containing substance suitable for human consumption with an aqueous solvent to produce an aqueous-ethanol monophase;
- said aqueous-ethanol monophase comprising from 15% ethanol in water (volume/volume) to 35% ethanol in water (volume/volume);
- and
- d) combining said solvent-diluted precursor stock produced in step (b) with said aqueous-ethanol monophase produced in step (c), wherein the ethanol-containing substance from said aqueous-ethanol monophase in step (c) becomes loaded as a passenger within the nanolipid particles (NLPs) in step (b) forming ethanol-loaded nanolipid particle (NLP) carriers, wherein said ethanol-loaded nanolipid particle (NLP) carriers are sized from 20 nm-300 nm.
Dependencies are inferred from the claim text.