Process for preparing polymers
AssigneeImperial Innovations Limited
InventorsMarc Shaepertoens, Piers Robert James Gaffney, Gyorgy Szekely, Andrew Guy Livingston
Life of this patent
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Abstract
A process for preparing non-naturally-occurring defined monomer sequence polymers is provided, and in which a high degree of synthetic control is obtained by the use of solvent resistant diafiltration membranes. Also provided is a process for separating non-naturally-occurring defined monomer sequence polymers from synthetic by-products or excess reagents using solvent resistant diafiltration membranes, and a use of a solvent resistant diafiltration membrane in processes for preparing and separating non-naturally-occurring defined monomer sequence polymers.
Claims15
A process for the preparation of a first compound being a non-naturally-occurring defined monomer sequence polymer, the process comprising the steps of:
- (i) synthesising the first compound by performing more than one sequential monomeric coupling reaction of monomer units in a first organic solvent, wherein
- all of the monomer units coupled in step (i) have an identical backbone moiety,
- at least two of the monomer units coupled in step (i) have a pendent side chain moiety, said pendent side chain moieties being distinct from each other, and
- at least four of the monomer units coupled in step (i) are distinct from each other;
- and
- (ii) between each coupling reaction, separating a product of the coupling reaction from at least one second compound, which is a reaction by-product of the synthesis of the product and/or an excess of a reagent used for the synthesis of the product;
- wherein during step (ii) the product of the coupling reaction and the at least one second compound are dissolved in a second organic solvent and are separated by a process of diafiltration using a membrane that is stable in the organic solvent and which provides a rejection for the product which is greater than the rejection for the second compound.
A process for the preparation of a first compound being a defined monomer sequence polymer, the process comprising the steps of:
- (i) synthesising the first compound by performing more than one sequential monomeric coupling reaction of monomer units in a first organic solvent, wherein
- all of the monomer units coupled in step (i) have an identical backbone moiety,
- at least two of the monomer units coupled in step (i) have a pendent side chain moiety, said pendent side chain moieties being distinct from each other, and
- at least four of the monomer units coupled in step (i) are distinct from each other;
- and
- (ii) between each coupling reaction, separating a product of the coupling reaction from at least one second compound, which is a reaction by-product of the synthesis of the product and/or an excess of a reagent used for the synthesis of the product;
- wherein during step (ii) the product of the coupling reaction and the at least one second compound are dissolved in a second organic solvent and are separated by a process of diafiltration using a membrane that is stable in the organic solvent and which provides a rejection for the product which is greater than the rejection for the second compound, with the proviso that the first compound is not an oligonucleotide, peptide or peptide nucleic acid.
Dependencies are inferred from the claim text.