Hyaluronic acid derivatives
AssigneeQueen's University at Kingston
InventorTassos Anastassiades
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Abstract
The present disclosure relates to hyaluronic acid derivatives, and in particular, derivatives in which the N-acetyl group of hyaluronic acid has been substituted, and methods and uses thereof.
Claims6
A pharmaceutical composition for treating skin inflammation, comprising:
- a pharmaceutically acceptable excipient or carrier, and a therapeutically effective amount of a hyaluronic acid derivative comprising repeating units of a disaccharide of Formula (I), wherein a portion of the disaccharide units of Formula (I) have been independently replaced with a disaccharide structure of Formula (II) wherein R is —C(O)—(C2-C4)-alkyl, or a pharmaceutically acceptable sodium- or potassium-salt, ester or glucoside thereof,
- wherein the hyaluronic acid derivative has a molecular weight of at least about 20 kDa, and
- wherein the hyaluronic acid derivative reduces production of inflammatory cytokines whereby when applied to skin, skin inflammation is treated, and wherein treating skin inflammation comprises treating loss of substance of the skin.
A method for the treatment of psoriasis or an inflammatory condition of the skin, comprising administering to a patient in need thereof a hyaluronic acid comprising repeating units of a disaccharide comprising glucuronic acid and N-acetylglucosamine, wherein a portion of the N-acetyl groups of the N-acetylglucosamine have been independently replaced with a group of the formula —N—C(O)—(C2-C4)-alkyl, and wherein the hyaluronic acid derivative has a molecular weight of at least about 20 kDa, or a pharmaceutically acceptable sodium or potassium salt, ester, or glucoside thereof.
Dependencies are inferred from the claim text.