Cyclodextrin
AssigneeCuradev Pharma Private Limited
InventorsTammy Savage, Stephen Wicks, John Mitchell
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Abstract
The invention provides a method for preparing sulphoalkyl ether-β-cyclodextrin. The method comprises first contacting cyclodextrin with a base to form activated cyclodextrin. The method then comprises separately contacting the activated cyclodextrin with an alkyl sultone to form sulphoalkyl ether-β-cyclodextrin. The activation reaction is carried in batch and the sulphoalkylation reaction is carried out under continuous flow conditions.
Claims13
A method for preparing sulphoalkyl ether-β-cyclodextrin, the method comprising contacting cyclodextrin with a base to form activated cyclodextrin, and separately contacting the activated cyclodextrin with an alkyl sultone to form sulphoalkyl ether-β-cyclodextrin, characterised in that the activation reaction is carried out as a batch process and the sulphoalkylation reaction is carried out under continuous flow conditions in a continuous stirred tank reactor (CSTR) or a flow reactor with efficient mixing and of suitable length to allow the sulphoalkylation reaction to complete within the reactor tubing;
- wherein the activation reaction is carried out in a first reservoir vessel, and the alkyl sultone is contained within a second reservoir vessel, and the first and second vessels are not directly connected to each other, such that the sultone and the base do not react with each other.
A method of preparing a pharmaceutical composition, the method comprising preparing a pharmaceutical excipient comprising sulphoalkyl ether β-cyclodextrin (SAE-β-CD),
- by contacting cyclodextrin with a base to form activated cyclodextrin, and separately contacting the activated cyclodextrin with an alkyl sultone to form sulphoalkyl ether-β-cyclodextrin, characterised in that the activation reaction is carried out as a batch process and the sulphoalkylation reaction is carried out under continuous flow conditions in a continuous stirred tank reactor (CSTR) or a flow reactor with efficient mixing and of suitable length to allow the sulphoalkylation reaction to complete within the reactor tubing, wherein the activation reaction is carried out in a first reservoir vessel, and the alkyl sultone is contained within a second reservoir vessel, and the first and second vessels are not directly connected to each other, such that the sultone and the base do not react with each other;
- and
- contacting the pharmaceutical excipient with an active pharmaceutical ingredient (API) to produce a pharmaceutical composition.
Dependencies are inferred from the claim text.