Nucleic acid encoding bone marrow stromal antigen 1 antibody
AssigneeOxford Biotherapeutics Ltd
InventorsChristian Rohlff, Jonathan Alexander Terrett
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Abstract
The invention provides antibodies which bind to the ADP-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of human cancers, including acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer and pancreatic cancer and human inflammatory diseases, including asthma, gout, crohns, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, diabetes and atherosclerotic.
Claims12
An isolated nucleic acid comprising a nucleotide sequence encoding an antibody variable region, wherein the antibody variable region comprises SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:46, or SEQ ID NO:49.
An isolated nucleic acid comprising a nucleotide sequence comprising SEQ ID NO:6, or SEQ ID NO:8.
Dependencies are inferred from the claim text.