Monoclonal antibody, inhibiting the enzymatic activity of vascular endothelial lipase

A monoclonal antibody that inhibits the enzymatic activity of vascular endothelial lipase or an antibody fragment thereof, wherein said antibody or fragment thereof recognizes at least four amino acid at positions of 50 to 100 in the amino acid sequence of SEQ ID NO:

• 1 including:
• 1) tyrosine at position 65, and
• 2) at least three amino acids selected from arginine at position 50, asparagine at position 52, arginine at position 54, aspartic acid at position 58, glutamic acid at position 60, histidine at position 61, glycine at position 63, and asparagine at position 100.