Anti-MUC1 antibody or antigen-binding fragment thereof and uses thereof

A monoclonal antibody to human MUC1, specifically recognizing human MUC1 tandem units and glycopeptides having a O-bond-type sugar chain core 0 (Tn) on any of the threonines or the serines in the amino acid sequence of the human MUC1 tandem units, wherein said antibody comprises at least one antigen-binding portion comprising an immunoglobulin heavy chain variable region (VH) domain and an immunoglobulin light chain variable region (VL) domain, with the heavy chain variable region domain comprising in the sequence thereof complementarity determining regions CDR1, CDR2, and CDR3, with CDR1 being comprised of the amino acid sequence shown by SEQ ID NO:

• 8, CDR2 being comprised of the amino acid sequence of SEQ ID NO:
• 9, and CDR3 being comprised of the amino acid sequence shown by SEQ ID NO:
• 10, with the light chain variable region domain comprising in the sequence thereof complementarity determining regions CDR1′, CDR2′, and CDR3′, with CDR1′ being comprised of the amino acid sequence shown by SEQ ID NO:
• 11, CDR2′ being comprised of the amino acid sequence of SEQ ID NO:
• 12, and CDR3′ being comprised of the amino acid sequence shown by SEQ ID NO:
• 13;
• or
• wherein said antibody comprises at least one antigen-binding portion comprising an immunoglobulin heavy chain variable region (VH) domain and an immunoglobulin light chain variable region (VL) domain, with the heavy chain variable region domain comprising in the sequence thereof complementarity determining regions CDR1, CDR2, and CDR3, with CDR1 being comprised of the amino acid sequence shown by SEQ ID NO:
• 16, CDR2 being comprised of the amino acid sequence of SEQ ID NO:
• 17, and CDR3 being comprised of the amino acid sequence shown by SEQ ID NO:
• 18, with the light chain variable region domain comprising in the sequence thereof complementarity determining regions CDR1′, CDR2′, and CDR3′, with CDR1′ being comprised of the amino acid sequence shown by SEQ ID NO:
• 19, CDR2′ being comprised of the amino acid sequence of SEQ ID NO:
• 20, and CDR3′ being comprised of the amino acid sequence shown by SEQ ID NO:
• 21.