Anti-CLL-1 antibodies and immunoconjugates
AssigneeGenentech, Inc.
InventorsBing Zheng, Andrew Polson, Cecilia Chiu, Wei-Ching Liang, Yan Wu
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Abstract
The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
Claims80
An isolated nucleic acid encoding an anti-CLL-1 antibody, wherein the antibody comprises
- (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:8;
- (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 11;
- (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 10;
- (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:5;
- (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:6;
- and
- (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:7.
An isolated nucleic acid encoding an anti-CLL-1 antibody, wherein the antibody comprises (a) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:34 and (b) a light chain variable region comprising the amino acid sequence of SEQ ID NO:32.
An isolated host cell comprising a first nucleic acid sequence and a second nucleic acid sequence, wherein the first nucleic acid sequence encodes a heavy chain variable region of an anti-CLL-1 antibody, wherein the heavy chain variable region comprises:
- (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:8;
- (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 11;
- (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 10;
- and the second nucleic acid sequence encodes a light chain variable region of the anti-CLL-1 antibody, wherein the light chain variable region comprises:
- (a) HVR-L1 comprising the amino acid sequence of SEQ ID NO:5;
- (b) HVR-L2 comprising the amino acid sequence of SEQ ID NO:6;
- and
- (c) HVR-L3 comprising the amino acid sequence of SEQ ID NO:7.
An isolated host cell comprising a first nucleic acid sequence and a second nucleic acid sequence, wherein the first nucleic acid sequence encodes a heavy chain variable region of an anti-CLL-1 antibody, wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:34, and the second nucleic acid sequence encodes a light chain variable region of the anti-CLL-1 antibody, wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO:32.
An isolated host cell that produces an anti-CLL-1 antibody, wherein the antibody comprises
- (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:8;
- (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 11;
- (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 10;
- (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:5;
- (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:6;
- and
- (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:7.
An isolated host cell that produces an anti-CLL-1 antibody, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:34 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:32.
Dependencies are inferred from the claim text.