Treatment of eosinophil or mast cell related disorders
AssigneeCelldex Therapeutics, Inc.
InventorsTheresa Marie LaVallee, Gerald McMahon
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and uses involving antibodies that specifically bind to a KIT receptor tyrosine kinase for managing, treating, or preventing an eosinophil or mast cell related disorder and/or one or more symptoms thereof, for example a mast cell related disorder of the nervous system, e.g., central nervous system, for example neuromyelitis optica (NMO), neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), and neurofibromatosis (NF).
Claims6
A method of inhibiting growth of neurofibromas in a subject, comprising administering to a subject diagnosed with neurofibromatosis (NF) a therapeutically effective amount of an antibody which specifically binds to a human KIT receptor (SEQ ID NO:
- 1), or an antigen binding fragment thereof, wherein the antibody or antigen binding fragment thereof comprises a light chain variable region (“VL”) comprising VL CDRs 1-3 comprising SEQ ID NOs:
- 2-4, respectively, and a heavy chain variable region (“VH”) comprising VH CDRs 1-3 comprising SEQ ID NOs:
- 5-7, respectively.
Dependencies are inferred from the claim text.