Anti-ED-A immunoconjugates for inflammatory bowel disease
AssigneePhilogen S.P.A.
InventorsGiovanni Neri, Kathrin Schwager, Melanie C. Ruzek, Denise M. O'hara, Jianqing Chen
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Abstract
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of treatment, diagnosis, detection and/or imaging of inflammatory bowel disease (IBD), and/or for use in delivery to the IBD tissue of a molecule conjugated to the specific binding member. The specific binding member may, for example, be conjugated to an immunosupressive or anti-inflammatory molecule, such as interleukin-10.
Claims16
A method of treating inflammatory bowel disease (IBD) in a patient, the method comprising administering to a patient a therapeutically effective amount of an antibody conjugate,
- wherein the antibody conjugate comprises an antibody, or an antigen-binding fragment thereof, that binds the Extra Domain-A (ED A) of fibronectin conjugated to human interleukin-10 (IL-10), wherein the antibody or antigen-binding fragment comprises a VH domain and a VL domain,
- wherein the VH domain comprises the heavy chain complementarity determining region (HCDR) 1, HCDR2, and HCDR3 amino acid sequences in SEQ ID NO:
- 7;
- and
- wherein the VL domain comprises the light chain complementarity determining region (LCDR) 1, LCDR2, and LCDR3 amino acid sequences in SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.