Human immunodeficiency virus neutralizing antibodies

An antibody or an antigen-binding fragment thereof, the antibody or antigen-binding fragment thereof comprising a heavy chain variable region and a light chain variable region, wherein:

• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:211 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:297;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:213 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:299;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:227 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:313;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:248 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:334;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:249 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:335;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:250 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:336;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:251 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:337;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:252 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:338;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:255 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:341;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:262 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:348;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:263 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:349;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:264 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:350;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:265 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:351;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:266 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:352;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:267 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:353;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:272 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:358;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:273 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:359;
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:274 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:360;
• or
• the heavy chain variable region comprises the amino acid sequence set forth in amino acids 1-132 of SEQ ID NO:275 and the light chain variable region comprises the amino acid sequence set forth in amino acids 1-105 of SEQ ID NO:361.