Back to results
US 10,239,913 B2Granted
Compounds and methods involving sterols
AssigneeWarsaw Orthopedic, Inc.
InventorsRoger E. Harrington, Jerbrena C. Jacobs, Damodaragounder Gopal, Ke-Qing Ling, Marco Burello
Life of this patent
Estimating the term…
Abstract
Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield. The compounds and methods provided can produce the oxysterol in a stereoselective manner. The method comprises reacting a diol with borane and hydrogen peroxide to form the oxysterol or a pharmaceutically acceptable salt, hydrate or solvate thereof.
Claims7
A method of making an oxysterol, the method comprising reacting a diol having the formula:
- with borane and hydrogen peroxide to form the oxysterol or a pharmaceutically acceptable salt, hydrate or solvate thereof having the formula:
- wherein R1 is a straight chain alkyl, and R2 is a straight chain alkyl and the hydrogen peroxide is reacted with the diol at a temperature of less than 15° C.
Dependencies are inferred from the claim text.