Pt (IV) derivatives and nanocarriers comprising them

A compound of formula (I), or a salt form thereof:

• wherein
• Pt is a platinum atom;
• A is a C8-C22 fatty acid associated with the Pt atom via an oxygen atom of the fatty acid;
• B is a C2-C7 fatty acid associated with the Pt atom via an oxygen atom of the fatty acid;
• provided that each of A and B is not C6-C9 branched alkyl fatty acid;
• L is a ligand atom or group of atoms selected from the group consisting of a halide atom, substituted or unsubstituted amine —NR1R2, —NH, ligand L1:
• wherein i is an integer between 0 and 5 and the ligand L1 associates to the Pt via the oxygen atoms,
• ligand L2:
• wherein j is an integer between 0 and 2, m is an integer between 0 and 6, and Ra is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkynyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, halogen, substituted or unsubstituted —NR1R2, substituted or unsubstituted —OR3, substituted or unsubstituted —SR4, substituted or unsubstituted —S(O)R5, substituted or unsubstituted alkylene-COOH, substituted or unsubstituted ester, OH, —SH, and —NH, phenyl and hydroxyl, and the ligand L2 associates to the Pt via the oxygen atoms,
• ligand L3:
• wherein k is an integer between 0 and 2, m is an integer between 0 and 6, and Rb is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkynyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, halogen, substituted or unsubstituted —NR1R2, substituted or unsubstituted —OR3, substituted or unsubstituted —SR4, substituted or unsubstituted —S(O)R5, substituted or unsubstituted alkylene-COOH, substituted or unsubstituted ester, OH, —SH, and —NH, phenyl, hydroxyl, and the ligand L3 associates to the Pt via the amine moieties,
• ligand L4:
• wherein the ligand L4 associates to the Pt via the amine moieties,
• ligand L5:
• wherein the ligand L5 associates to the Pt via the amine moiety;
• and
• n is the number of ligand moieties, being 1, 2, 3, or 4,
• wherein, in each of L1-L5, R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heterocyclyl, halide, —C(O)NR6R7, sulfinyl, ester, and carbonyl, or R1 and R2 form a cyclic structure with the N atom they are bonded to,
• each of R3, R4, and R5 is independently selected from hydrogen, alkyl, alkenyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heterocyclyl, halide, sulfinyl, ester, and carbonyl, and
• R6 and R7 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heterocyclyl, halide, sulfinyl, ester, carbonyl, —OH, —SH and NH,
• wherein at least one ligand L is bound to the platinum atom via at least one heteroatom selected from nitrogen, oxygen and sulfur.