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US 10,239,891 B2Granted
Compositions to detect remnant cancer cells
AssigneeIndicator Systems International, Inc.
InventorsGerald F. Swiss, Richard J. Pariza, Robert M. Moriarty
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds, compositions and methods for detecting remnant cancer cells in a tissue sample.
Claims9
A compound of formula I:
- where:
- R and R1 are independently C2-C18 alkyl or cycloalkyl groups either or both optionally containing 1 to 8 heteroatoms selected from the group consisting of oxygen, S(O)x, >NR3, —OP(O)yH, —OS(O)zH, —C(O)—, amino, C1-C6 alkylamino, di(C1-C6 dialkyl)amino, —C(O)O—, —C(O)NR3—, —C(O)OH, —OH, and oxo wherein y and z are independently 1 or 2, and x is 0, 1 or 2;
- R3 is hydrogen or C1-C6 alkyl;
- and
- L is a linker of from 1 to 20 carbon atoms and 1 to 6 heteroatoms;
- selected from the group consisting of oxygen, S(O)x, >NR3, —OP(O)yH, —OS(O)H, —C(O)—, amino, C1-C6 alkylamino, di(C1-C6 dialkyl)amino, —C(O)O—, —C(O)NR3—, —C(O)OH, —OH, and oxo wherein y and z are independently 1 or 2, and x is 0, 1 or 2;
- and
- or pharmaceutically acceptable salts and/or solvates thereof.
5 more elements
A compound of formula II:
- where:
- R and R1 are independently C2-C18 alkyl or cycloalkyl groups either or both optionally containing 1 to 8 heteroatoms selected from the group consisting of oxygen, S(O)x, >NR3, —OP(O)yH, —OS(O)zH, —C(O)—, amino, C1-C6 alkylamino, di(C1-C6 dialkyl)amino, —C(O)O—, —C(O)NR3—, —C(O)OH, —OH, and oxo wherein y and z are independently 1 or 2, and x is 0, 1 or 2;
- R3 is hydrogen or C1-C6 alkyl;
- and
- L is a linker of from 1 to 20 carbon atoms and 1 to 6 heteroatoms;
- selected from the group consisting of oxygen, S(O)x, >NR3, —OP(O)yH, —OS(O)H, —C(O)—, amino, C1-C6 alkylamino, di(C1-C6 dialkyl)amino, —C(O)O—, —C(O)NR3—, —C(O)OH, —OH, and oxo wherein y and z are independently 1 or 2, and x is 0, 1 or 2;
- and
- or pharmaceutically acceptable salts and/or solvates thereof.
5 more elements
A compound of formula III:
- where:
- R and R1 are independently C2-C18 alkyl or cycloalkyl groups either or both optionally containing 1 to 8 heteroatoms selected from the group consisting of oxygen, S(O)x, >NR3, —OP(O)yH, —OS(O)zH, —C(O)—, amino, C1-C6 alkylamino, di(C1-C6 dialkyl)amino, —C(O)O—, —C(O)NR3—, —C(O)OH, —OH, and oxo wherein y and z are independently 1 or 2, and x is 0, 1 or 2;
- R3 is hydrogen or C1-C6 alkyl;
- and
- L is a linker of from 1 to 20 carbon atoms and 1 to 6 heteroatoms;
- selected from the group consisting of oxygen, S(O)x, >NR3, —OP(O)yH, —OS(O)zH, —C(O)—, amino, C1-C6 alkylamino, di(C1-C6 dialkyl)amino, —C(O)O—, —C(O)NR3—, —C(O)OH, —OH, and oxo wherein y and z are independently 1 or 2, and x is 0, 1 or 2;
- or a pharmaceutically acceptable salt and/or solvate thereof.
4 more elements
A pharmaceutical composition comprising a pharmaceutically acceptable inert diluent and a compound of formula I, II, or III.
A compound, salts and solvates of formula selected from the group consisting of:
- #
- R/R1
- R2
- L
- 1
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- H
- 2
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- CH3
- 3
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/
- H
- —NHCH2CH2CH2(OCH2CH2)3CH2NHC(═S)NH—
- CH3OCH2CH2OC(O)CH2CH2C(O)O—
- 4
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- H
- 5
- CH3OCH2CH2OC(O)CH2CH2C(O)O— CH3OCH2CH2OC(O)CH2CH2C(O)O—
- H
- 6
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3CH2C(O)O—
- H
- 7
- CH3O2C(CH2CH2O)3C(O)(CH2CH2O)3C(O)O— CH3O2C(CH2CH2O)3C(O)(CH2CH2O)3C(O)O—
- H
- 8
- CH3O(CH2CH2O)2CH2C(O)O—/ CH3O(CH2CH2O)2CH2C(O)O—
- H
- .
28 more elements
A compound, salts and solvates of formula selected from the group consisting of:
- No.
- R/R1
- L
- 9
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- 10
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- 11
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- 12
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- 13
- CH3OCH2CH2OC(O)CH2CH2C(O)O— CH3OCH2CH2OC(O)CH2CH2C(O)O—
- 14
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3CH2C(O)O—
- 15
- CH3O2C(CH2CH2O)3C(O)(CH2CH2O)3C(O)O—
- 16
- CH3O(CH2CH2O)4CH2CH2C(O)O—/ CH3O(CH2CH2O)4CH2CH2C(O)O—
- .
17 more elements
A compound, salts and solvates of formula selected from the group consisting of:
- Compound
- No.
- R/R1
- L
- 17
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- —C(═S)NH—
- 18
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- —CH2CH2CH2NHC(═S)NH—
- 19
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- —CH2NHC(═S)NH—
- 20
- CH3OCH2CH2OC(O)CH2CH2C(O)O—/ CH3OCH2CH2OC(O)CH2CH2C(O)O—
- —CH2CH2NHC(═S)NH—
- 21
- CH3OCH2CH2OC(O)CH2CH2C(O)O— CH3OCH2CH2OC(O)CH2CH2C(O)O—
- —CH2CH2NHC(═O)NH—
- 22
- CH3OCH2CH2OC(O)CH2CH2C(O)—/ CH3CH2C(O)—
- —C(═S)NH—
- 23
- CH3O2C(CH2CH2O)3C(O)(CH2CH2O)3C(O)—
- —CH2NHC(═S)NH—
- 24
- CH3O(CH2CH2O)4CH2CH2C(O)O—/ CH3O(CH2CH2O)4CH2CH2C(O)O—
- CH2NHC═S)NH—
- 25
- .
- —CH2CH2NHC(═S)NH—
28 more elements
Dependencies are inferred from the claim text.