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US 10,239,889 B1Granted
Pentacyclic compound
AssigneeEisai R&D Management Co., Ltd.
InventorsYoshiaki Ohashi, Yoshihiko Norimine, Tamaki Hoshikawa, Yu Yoshida, Yoshihisa Kobayashi, Nobuhiro Sato, Koji Hagiwara
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds represented by formulas (1) to (VI) or pharmaceutically acceptable salts thereof:
Claims12
A compound selected from the group consisting of:
- 3-fluoro-6,11-dimethyl-6,7,10,11,12,13-hexahydrobenzo[f]pyrido[4″,3″:4′,5′]thieno[2′,3′:4,5]pyrimido[1,2-a][1,4]diazepine-5,14-dione:
- 5,10-dimethyl-5,6,9,10,11,12-hexahydropyrido[4″,3″:4′,5′]thieno[2′,3′:4,5]pyrimido[1,2-a]thieno[2,3-f][1,4]diazepine-4,13-dione:
- 5,10-dimethyl-5,6,9,10,11,12-hexahydropyrido[4″,3″:4′,5′]thieno[2′,3′:4,5]pyrimido[1,2-a]thieno[3,2-][1,4]diazepine-4,13-dione:
- (3aS,14aR)-5,10-dimethyl-3,3a,5,6,9,10,11,12-octahydro-1H-cyclopenta[f]pyrido[4″,3″:4′,5′]thieno[2′,3′:4,5]pyrimido[1,2-a][1,4]diazepine-4,13(2H,14aH)-dione:
- (3aR,14aR)-5,10-dimethyl-3,3a,5,6,9,10,11,12-octahydro-1H-cyclopenta[f]pyrido[4″,3″:4′,5′]thieno[2′,3′:4,5]pyrimido[1,2-a][1,4]diazepine-4,13(2H,14aH)-dione:
- and
- (3aS,14aS)-5,10-dimethyl-3,3a,5,6,9,10,11,12-octahydro-1H-cyclopenta[ft]pyrido[4″,3″:4′,5′]thieno[2′,3′:4,5]pyrimido[1,2-a][1,4]diazepine-4,13(2H,14aH)-dione:
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.