Macrocyclic ligands with pendant chelating moieties and complexes thereof

A compound of the structure:

• wherein
• Ab1 and Ab2 are members independently selected from:
• wherein
• each R7, and R8 is independently selected from a bond to L1 or L2, alkanediyl attached to L1 or L2, H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, halogen, CN, —CF3, —C(O)R17, —SO2NR17R18, —NR17R18, —OR17, —S(O)2R17, —COOR17, —S(O)2OR17, —OC(O)R17, —C(O)NR17R18, —NR17C(O)R18, —NR17SO2R18, and —NO2,
• wherein
• R17 and R18 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl;
• or
• R17 and R18, together with the atoms to which they are attached, are optionally joined to form a 5-, 6- or 7-membered ring;
• L1a is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted biaryl, substituted or unsubstituted heteroaryl, and a substituted or unsubstituted polycyclic ring system;
• Lx6 is independently selected from H, a linker to a reactive functional group, and a linker to a targeting moiety
• wherein,
• the linker to a reactive functional group, and the linker to a targeting moiety are independently selected from a bond, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl, —C(O)NR′—, —C(O)O—, —C(O)S—, and —C(O)CR′R″, wherein R′ and R″ are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl;
• the reactive functional group is selected from olefins, acetylenes, alcohols, phenols, ethers, oxides, halides, aldehydes, ketones, carboxylic acids, esters, amides, cyanates, isocyanates, thiocyanates, isothiocyanates, amines, hydrazines, hydrazones, hydrazides, diazo, diazonium, nitro, nitriles, mercaptans, sulfides, disulfides, sulfoxides, sulfones, sulfonic acids, sulfinic acids, acetals, ketals, anhydrides, sulfates, sulfenic acids isonitriles, amidines, imides, imidates, nitrones, hydroxylamines, oximes, hydroxamic acids thiohydroxamic acids, allenes, ortho esters, sulfites, enamines, ynamines, ureas, pseudoureas, semicarbazides, carbodiimides, carbamates, imines, azides, azo compounds, azoxy compounds, and nitroso compounds;
• and
• the targeting moiety is selected from antibodies, nucleic acids, oligonucleotides, carbohydrates, lipids, hormones, growth factors, lectins, receptors, receptor ligands, and cofactors;
• L2a, L2b and L2c are independently selected from substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl;
• wherein Ap1, and Ap2 are independently selected from:
• wherein
• A and G are independently selected from carbon, nitrogen and oxygen;
• J is selected from carbon and nitrogen;
• each R1′ and R2′ is independently selected from H, and a single negative charge;
• each R6′, R7′, R8′, R9′, and R10 ′ moiety is independently selected from a bond linking the moiety to the remainder of the compound, alkanediyl linking the moiety to the remainder of the molecule, H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, halogen, CN, —CF3, —C(O)R17′, —SO2NR17′R18′, —NR17′R18′, —OR17′, —S(O)2R17′, —COOR17′, —S(O)2OR17′, —OC(O)R17′, —C(O)NR17′R18′, —NR17′SO2R18′, and —NO2,
• wherein
• at least two of R6′, R7′, R8′, R9′, and R10′ are optionally joined to form a ring system selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• R17′ and R18′ are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl;
• or
• R17′ and R18′, together with the atoms to which they are attached, are optionally joined to form a 5-, 6- or 7-membered ring;
• when A is oxygen, R9′ is not present;
• and
• when G is oxygen, R7′ is not present;
• and
• Ap1 and Ap2 are attached to C1 and C2, respectively, through a member selected from R6′, R7′, R8′, R9′ and R10′.