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US 10,239,867 B2Granted
Modulators of ATP-binding cassette transporters
AssigneeVertex Pharmaceuticals Incorporated
InventorsSara S. Hadida Ruah, Peter D. J. Grootenhuis, Fredrick Van Goor, Jinglan Zhou, Brian Bear, Mark T. Miller, Jason McCartney, Mehdi Michel Jamel Numa, Xiaoqing Yang
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Abstract
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Claims12
A compound of formula IId:
- or a pharmaceutically acceptable salt thereof;
- wherein
- both R2 groups, together with the atoms to which they are attached, form the group:
- R′3 is selected from —CH2CH2 and
- and
- each R3 is independently selected from
- H, and F.
4 more elements
Dependencies are inferred from the claim text.