2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof
AssigneeBeta Pharma, Inc.
InventorsMichael Nicholas Greco, Michael John Costanzo, Jirong Peng, Victoria Lynn Wilde, Don Zhang
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Abstract
Indazole compounds of formula (I) as cyclin-dependent kinase (CDK) and cell-proliferation inhibitors, and therapeutic uses and methods of preparation thereof, are disclosed. These compounds, and pharmaceutically acceptable salts, solvates, prodrugs, and pharmaceutical compositions thereof, are useful for treating diseases and disorders associated with activity of cyclin-dependent kinases, in particular CDK4/6, including but not limited to various cancers and inflammation-related diseases or conditions.
Claims20
A compound of formula (Ia)
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is hydrogen or ethyl;
- R2 is isopropyl;
- R3 is methyl;
- R4 is hydrogen or halogen;
- and
- R5 is hydrogen or halogen.
A method of preparing a compound of formula (Ia), comprising a step of coupling intermediate E with intermediate G:
- wherein R1 is ethyl, R2 is isopropyl, R3 is methyl, R4 is hydrogen or fluoro, and R5 is hydrogen or fluoro, and X3 is Cl, Br, or I.
Dependencies are inferred from the claim text.