Factor XIa inhibitors

A compound of Formula I

• or a pharmaceutically acceptable salt thereof, wherein
• R2 is
• 1) phenyl,
• 2) R21,
• 3) 4-7-membered saturated carbocycle,
• 4) —OR21, or
• wherein R21 is 4-7-membered unsaturated or saturated heterocycle containing one or two heteroatoms independently selected from the N, O and S,
• wherein phenyl is unsubstituted or monosubstituted with CF3, and heterocycle is unsubstituted or monosubstituted with NH2, SO2CH3 or COCH3;
• R6 is
• 1) —CH═CH—R63,
• 2) —CH2CH2—R63,
• 3) 4-7-membered monocyclic saturated heterocycle having one or two heteroatoms independently selected from N, O and S,
• 4) R62,
• 5) 7-9-membered bicyclic unsaturated carbocycle,
• wherein R63 is phenyl which is mono, di or trisubstituted with a substituent independently selected from halogen, CF3 and tetrazole, saturated heterocycle is unsubstituted or substituted at the nitrogen atom with —C(NH)NH2, and R62 is unsaturated or saturated carbocycle unsubstituted or independently substituted with one or two of —CH2NH2, NH2, C(CH3)2NH2, C1-6 alkyl, or C3-8 cycloalkyl, or
• wherein R61 is —(CH2)0-1NH2;
• R4 is
• 1) —CH2OR41, wherein R41 is hydrogen or —Si(C1-6 alkyl)(C1-6 alkyl)(C1-6 alkyl),
• 2) phenyl,
• 3) 3-7-membered monocyclic saturated carbocycle,
• 4) C1-6 alkyl, or
• 5) —O—R42, wherein R42 is a 4-7-membered monocyclic saturated heterocycle having one or two heteroatoms independently selected from N, O and S,
• wherein phenyl is unsubstituted or substituted with one or two substituents independently selected from CF3, halogen, NH2, OCF3, C(O)NH2, C1-6 alkyl or
• R5 is
• 1) —C(O)NHR51 wherein
• R51 is
• a) 3-7-membered monocyclic saturated or unsaturated carbocycle,
• b) 8-membered bicyclic saturated carbocycle, or
• c) 9-membered bicyclic unsaturated heterocycle
• wherein carbocycle is unsubstituted or substituted with one or two substituents independently selected from C(O)OC(C1-6 alkyl)(C1-6 alkyl)(C1-6 alkyl) or C(O)OH, and wherein heterocycle containing one or two heteroatoms selected from N, O and S, is unsubstituted or substituted with methyl,
• wherein
• R52 is
• a) 3-7-membered monocyclic saturated or unsaturated carbocycle,
• b) 6-membered unsaturated heterocycle containing 1 nitrogen atom, or
• c) 9-membered bicyclic unsaturated heterocycle containing 1 or 2 heteroatoms, selected from N and O
• wherein carbocycle is unsubstituted or substituted with one or two substituents independently selected from CN, halogen, OC1-6 alkyl, SO2C1-6 alkyl, CF3, C(O)OC1-6 alkyl, NH2, NHC(O)OC1-6 alkyl, NHC(O)C1-6 alkyl, C(O)OC(CH3)2, C(O)OH, PO3H2, or PO3(C1-6 alkyl)2, wherein heterocycle is unsubstituted or substituted with methyl, and wherein bicyclic heterocycle is unsubstituted or substituted with a ═O, and
• R53 is hydrogen, halogen or C1-6 alkyl, and
• wherein
• R54 is hydrogen or halogen.