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US 10,239,840 B2Granted
Benzoazepine derivatives
AssigneeViiV Healthcare UK Limited
InventorsBrian Alvin Johns, Lita S. Suwandi, Emile Johann Velthuisen, Jason Gordon Weatherhead
Life of this patent
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Abstract
Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds.
Claims11
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof wherein:
- R1 is C1-6alkyl;
- R2 is C5-14aryl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-9heterocycle, or C5-9heteroaryl, wherein each R2 group is optionally substituted by one to four substituents selected from halo, C1-6alkyl, C1-6heteroalkyl, or C1-6alkylene or C1-6heteroalkylene wherein said C1-6alkylene or C1-6heteroalkylene are bonded to adjacent carbon atoms on said C5-14aryl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-9heterocycle, or C5-9heteroaryl to form a fused ring;
- L is a bond —C1-3alkylene-, —SO2—, —C(O)—, —C(S)—, —C(NH)—, —C(O)NH—, —C(O)NHCH2—, —C(O)OCH2—, —C(O)O—, —C(O)C(O)—, —SO2—NH—, or —CH2C(O)—;
- R3 is H, CN, C1-6alkyl, C5-14aryl, CH2C5-14aryl, CH2C3-7cycloalkyl, C3-7cycloalkyl, C3-7spirocycloalkyl, C3-7cycloalkenyl, C3-9heterocycle, or C5-9heteroaryl, wherein each R3 group is optionally substituted by one to four substituents selected from halo, C1-6alkyl, C2-8bridgedheterocycle, C3-7cycloalkyl, C1-3fluoroalkyl, —OC1-6alkyl, —C(O)R4, —C(O)NR4, —C(O)NHR4, C5-14aryl, C1-6heteroalkyl, —B(OH)2, C3-9heterocycle, C5-6heteroaryl, —C(O)OC1-6alkyl, or two substituents bonded to adjacent atoms may bond together to form a fused ring and that fused ring may optionally be substituted with R4, wherein R4 is CN, halo, —OC1-6alkyl, C1-6alkyl, C3-7cycloalkyl, C3-9heterocycle, or C5-14aryl;
- each R5 is independently H, halogen, C1-6alkyl, or C3-7cycloalkyl, wherein each C1-6alkyl and C3-7cycloalkyl may optionally be substituted with 1-3 halogen atoms;
- and
- and wherein each heterocycle, heteroaryl, heteroalkyl, and heteroalkylene comprises one to three heteroatoms selected from S, N, B, or O.
5 more elements
Dependencies are inferred from the claim text.