Antibiotic sensitivity-restoring and photosensitive agents
AssigneeNew Mexico Tech University Research Park Corporation
InventorsSnezna Rogelj, Liliya Frolova, Alexander Kornienko, Leslie D. Edwards, Cody Champion, Kailee Zingler, Danielle Nicole Turner
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Abstract
The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to white light, can be activated. The photosensitive compound can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria. The photosensitive compounds can also be used to inhibit the proliferation of cancer cells.
Claims32
A method of treating an infection, the method comprising administering to a subject in need thereof a therapeutically-effective amount of a compound and an antibiotic, wherein the compound is of the formula:
- wherein:
- R1 is hydrogen;
- R2 is hydrogen;
- R3 is L2-Ar2;
- L2 is N═N or CH═CH;
- Ar2 is phenyl substituted with halogen;
- and
- each A1, A2, A3, and A4 is independently C(R1a), wherein R1a is hydrogen, or a pharmaceutically-acceptable salt thereof, wherein the compound is more effective in the presence of light than in the dark.
Dependencies are inferred from the claim text.