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AssigneeNanobacterie
InventorsEdouard Alphandery, Stéphanie Faure, Imène Chebbi
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A method for the treatment of tumor(s) or tumor cell(s) or cancer(s) in a subject in need by the generation of heat. The latter is produced by chains of magnetosomes extracted from whole magnetotactic bacteria and subjected to an alternating magnetic field. These chains of magnetosomes yield efficient antitumoral activity whereas magnetosomes unbound from the chains or kept within the whole bacteria produce poor or no antitumoral activity. The introduction of various chemicals such as chelating agents and/or transition metals within the growth medium of the bacteria improves the heating properties of the chains of magnetosomes. Moreover, the insertion of the chains of magnetosomes within a lipid vesicle is also suggested in order to favor their rotation in vivo and hence to improve their heating capacity. The vesicle can contain an antitumoral agent together with the chains of magnetosomes. In this case, the agent is released within the tumors by heating the vesicle.
A method of treating a tumor or tumor cells by heat therapy in a subject in need thereof, comprising administering to the subject chains of bacterial magnetosomes, wherein:
A kit comprising chains of bacterial magnetosomes and a device, which is able to generate an alternating magnetic field, said chains of bacterial magnetosomes comprise maghemite, and have a lower surface charge at a pH of 10 than at a pH of 2.
A method for the production of chains of magnetosomes comprising cultivating magnetotactic bacteria in a growth medium containing at least an iron source with or without a chelating agent, wherein (i) said chains of magnetosomes comprise maghemite, (ii) said chains of magnetosomes have a lower surface charge at a pH of 10 than at a pH of 2, and (iii) most of the magnetosomes of said chains possess crystallographic directions orientated in the direction of the chain elongation.
A composition comprising chains of bacterial magnetosomes isolated from magnetotactic bacteria wherein:
Dependencies are inferred from the claim text.